Cubs vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 4:11 a.m.

The MLB's Friday schedule includes the Chicago Cubs facing the Boston Red Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Cubs vs Red Sox Game Info

• Chicago Cubs (88-71) vs. Boston Red Sox (85-74)
• Date: Friday, September 25, 2026
• Time: 1:05 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and MARQ

Cubs vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | BOS: (-102)
• Spread: CHC: -1.5 (+162) | BOS: +1.5 (-196)
• Total: 6.5 -- Over: (-114) | Under: (-106)

Cubs vs Red Sox Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-8, 3.25 ERA vs Alec Gamboa (Red Sox) - 1-0, 1.16 ERA

This contest's pitching matchup is set, as the Cubs will send Clay Holmes (6-8) to the mound, while Alec Gamboa (1-0) will answer the bell for the Red Sox. Holmes' team is 6-11-0 against the spread this season in his starts. Holmes' team has won 50% of his starts when they are favored on the moneyline (6-6). Gamboa has started two games with set spreads, and the Red Sox went 1-1-0. The Red Sox were named the moneyline underdog for one Gamboa start this season -- they lost.

Cubs vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.3%)

Cubs vs Red Sox Moneyline

• The Cubs vs Red Sox moneyline has Chicago as a -116 favorite, while Boston is a -102 underdog at home.

Cubs vs Red Sox Spread

• The Red Sox are at +1.5 on the runline against the Cubs. The Red Sox are -196 to cover the spread, and the Cubs are +162.

Cubs vs Red Sox Over/Under

• Cubs versus Red Sox, on Sept. 25, has an over/under of 6.5, with the over being -114 and the under -106.

Bet on Chicago Cubs vs. Boston Red Sox on FanDuel today!

Cubs vs Red Sox Betting Trends

• The Cubs have come away with 60 wins in the 106 contests they have been listed as the favorites in this season.
• Chicago has a record of 55-44 in contests when oddsmakers favor them by -116 or more on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 87 of 154 chances this season.
• The Cubs have an against the spread mark of 73-81-0 in 154 games with a line this season.
• The Red Sox have won 47.7% of the games this season they were the moneyline underdog (21-23).
• When playing as a moneyline underdog with odds of -102 or longer, Boston has gone 16-22 (42.1%).
• The Red Sox have combined with opponents to go over the total 68 times this season for a 68-86-2 record against the over/under.
• The Red Sox are 73-83-0 ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.373), slugging percentage (.575) and total hits (173) this season. He has a .280 batting average.
• He ranks 22nd in batting average, 13th in on-base percentage, and second in slugging among qualified hitters in MLB.
• Alex Bregman is batting .262 with 32 doubles, two triples, 26 home runs and 75 walks. He's slugging .452 with an on-base percentage of .352.
• His batting average is 55th among qualified players, his on-base percentage 41st, and his slugging percentage 42nd.
• Seiya Suzuki is batting .270 with a .476 slugging percentage and 86 RBI this year.
• Suzuki has recorded at least one base hit in six games in a row. During his last 10 outings he is batting .262 with a double, two home runs, three walks and five RBIs.
• Nico Hoerner has been key for Chicago with 163 hits, an OBP of .318 plus a slugging percentage of .353.
• Hoerner heads into this game on a two-game hitting streak. During his last five outings he is hitting .278 with a double, two walks and three RBIs.

Red Sox Player Leaders

• Wilyer Abreu has 37 doubles, four triples, 24 home runs and 70 walks while batting .251. He's slugging .451 with an on-base percentage of .330.
• Including all qualified hitters in the big leagues, his batting average puts him 77th, his on-base percentage ranks 69th, and he is 45th in slugging.
• Caleb Durbin is hitting .250 with 25 doubles, a triple, 13 home runs and 51 walks. He's slugging .382 with an on-base percentage of .335.
• He is currently 80th in batting average, 59th in on-base percentage and 105th in slugging percentage among all qualified hitters.
• Willson Contreras has totaled 123 hits with a .387 on-base percentage, leading the Red Sox in both statistics.
• Ceddanne Rafaela's .442 slugging percentage paces his team.

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