Cubs vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 6:11 a.m.

Wednesday's slate in the MLB includes a matchup between the Chicago Cubs and the San Francisco Giants.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Giants Game Info

• Chicago Cubs (76-56) vs. San Francisco Giants (64-68)
• Date: Wednesday, August 27, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and MARQ

Cubs vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-126) | SF: (+108)
• Spread: CHC: -1.5 (+136) | SF: +1.5 (-164)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Cubs vs Giants Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 10-5, 3.96 ERA vs Carson Whisenhunt (Giants) - 1-1, 4.91 ERA

The Cubs will give the nod to Colin Rea (10-5, 3.96 ERA), who is eyeing win No. 11 on the season, and the Giants will turn to Carson Whisenhunt (1-1, 4.91 ERA). Rea's team is 13-8-0 against the spread in his starts this season. Rea's team is 8-5 this season when he starts and they are the moneyline favorite. The Giants have a 2-2-0 ATS record in Whisenhunt's four starts with a set spread. The Giants were the underdog on the moneyline for two Whisenhunt starts this season -- they split the games.

Cubs vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (58.6%)

Cubs vs Giants Moneyline

• San Francisco is a +108 underdog on the moneyline, while Chicago is a -126 favorite on the road.

Cubs vs Giants Spread

• The Giants are at +1.5 on the runline against the Cubs. The Giants are -164 to cover the spread, and the Cubs are +136.

Cubs vs Giants Over/Under

• Cubs versus Giants, on Aug. 27, has an over/under of 8.5, with the over being -108 and the under -112.

Bet on Chicago Cubs vs. San Francisco Giants on FanDuel today!

Cubs vs Giants Betting Trends

• The Cubs have been chosen as favorites in 88 games this year and have walked away with the win 57 times (64.8%) in those games.
• Chicago has a record of 49-23 in contests when sportsbooks favor them by -126 or more on the moneyline.
• The Cubs' games have gone over the total in 59 of their 128 opportunities.
• The Cubs are 60-68-0 against the spread in their 128 games with a line set by sportsbooks this season.
• The Giants have been the moneyline underdog 52 total times this season. They've finished 24-28 in those games.
• San Francisco is 17-20 (winning 45.9% of its games) when playing as a moneyline underdog of +108 or longer.
• In the 131 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 60 times (60-65-6).
• The Giants have covered 43.5% of their games this season, going 57-74-0 against the spread.

Cubs Player Leaders

• Kyle Tucker has 122 hits this season and a team-best OBP of .374. He has a .262 batting average and a slugging percentage of .462.
• He is 68th in batting average, 10th in on-base percentage, and 52nd in slugging among qualified hitters in the majors.
• Tucker hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .300 with a double, three home runs, three walks and seven RBIs.
• Pete Crow-Armstrong leads Chicago with 127 hits. He is batting .256 this season and has 66 extra-base hits. He's also slugging .510 with an on-base percentage of .295.
• He ranks 87th in batting average, 142nd in on-base percentage and 15th in slugging in MLB.
• Nico Hoerner has an OPS of .707, fueled by an OBP of .337 and a team-best slugging percentage of .370 this season.
• Seiya Suzuki is batting .244 with a .319 OBP and 87 RBI for Chicago this season.
• Suzuki brings a three-game hitting streak into this game. In his last five games he is batting .167 with four walks and an RBI.

Giants Player Leaders

• Rafael Devers has put up a team-best OBP (.372), while pacing the Giants in hits (124). He's batting .252 and slugging.
• Including all the qualifying players in MLB, he is 93rd in batting average, 13th in on-base percentage and 53rd in slugging percentage.
• Jung Hoo Lee is hitting .259 with 29 doubles, 10 triples, seven home runs and 41 walks. He's slugging .408 with an on-base percentage of .322.
• His batting average is 77th among all qualified players, his on-base percentage is 92nd, and he is 98th in slugging.
• Willy Adames is batting .223 with 18 doubles, two triples, 22 home runs and 63 walks.
• Heliot Ramos paces his team with a .404 slugging percentage.

Cubs vs Giants Head to Head

• 8/26/2025: 5-2 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/7/2025: 3-1 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2025: 14-5 SF (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/5/2025: 9-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/27/2024: 5-3 CHC (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/26/2024: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/25/2024: 5-1 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/24/2024: 5-4 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/19/2024: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/18/2024: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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