Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 6:11 a.m.

The St. Louis Cardinals will take on the Pittsburgh Pirates in MLB action on Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (65-68) vs. Pittsburgh Pirates (58-75)
• Date: Wednesday, August 27, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Fox Sports 1, FDSMW, and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-178) | PIT: (+150)
• Spread: STL: -1.5 (+122) | PIT: +1.5 (-146)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 12-6, 4.33 ERA vs Carmen Mlodzinski (Pirates) - 3-7, 3.89 ERA

The Cardinals will give the nod to Sonny Gray (12-6, 4.33 ERA), who is eyeing win No. 13 on the season, and the Pirates will counter with Carmen Mlodzinski (3-7, 3.89 ERA). Gray and his team have a record of 13-11-0 against the spread when he starts. Gray's team has won 75% of his starts when they are favored on the moneyline (12-4). When Mlodzinski starts, the Pirates are 5-5-0 against the spread. The Pirates are 3-7 in Mlodzinski's 10 starts this season that they were the underdog on the moneyline.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (60.1%)

Cardinals vs Pirates Moneyline

• Looking at the moneyline for Pirates-Cardinals, Pittsburgh is the underdog at +150, and St. Louis is -178 playing at home.

Cardinals vs Pirates Spread

• The Pirates are +1.5 on the spread (-146 to cover), and St. Louis is +122 to cover the runline.

Cardinals vs Pirates Over/Under

• A total of 7.5 runs has been set for the Cardinals-Pirates game on Aug. 27, with the over available at -100 and the under at -122.

Bet on St. Louis Cardinals vs. Pittsburgh Pirates on FanDuel today!

Cardinals vs Pirates Betting Trends

• The Cardinals have been chosen as favorites in 57 games this year and have walked away with the win 29 times (50.9%) in those games.
• St. Louis has a record of 3-2 in contests when sportsbooks favor them by -178 or more on the moneyline.
• The Cardinals and their opponents have hit the over in 67 of their 127 games with a total set by oddsmakers this season.
• In 127 games with a line this season, the Cardinals have a mark of 64-63-0 against the spread.
• The Pirates have gone 35-50 in games they were listed as the moneyline underdog (winning 41.2% of those games).
• Pittsburgh has gone 9-19 when it has played as a moneyline underdog with odds of +150 or longer (32.1%).
• In the 125 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 50 times (50-69-6).
• The Pirates are 68-57-0 against the spread this season.

Cardinals Player Leaders

• Alec Burleson has 123 hits to go with a slugging percentage of .459, both of which lead St. Louis hitters this season. He has a .291 batting average and an on-base percentage of .341.
• Among qualified hitters in MLB, he ranks 15th in batting average, 56th in on-base percentage, and 54th in slugging.
• Burleson hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .364 with a double, a home run and three RBIs.
• Willson Contreras has 30 doubles, 19 home runs and 40 walks. He's batting .259 and slugging .455 with an on-base percentage of .343.
• Among qualified hitters, he is 77th in batting average, 53rd in on-base percentage and 59th in slugging percentage.
• Masyn Winn has 116 hits this season and has a slash line of .256/.310/.372.
• Lars Nootbaar is batting .234 with a .326 OBP and 44 RBI for St. Louis this season.

Pirates Player Leaders

• Bryan Reynolds has accumulated a team-high slugging percentage (.414) and paces the Pirates in hits (122). He's batting .247 and with an on-base percentage of .306.
• Including all qualifying hitters, he is 103rd in batting average, while his on-base percentage ranks 122nd and he is 92nd in slugging.
• Oneil Cruz has 17 doubles, two triples, 18 home runs and 55 walks while hitting .205. He's slugging .394 with an on-base percentage of .303.
• Including all qualified hitters, he ranks 156th in batting average, 127th in on-base percentage and 118th in slugging percentage.
• Andrew McCutchen a has .333 on-base percentage to pace the Pirates.
• Isiah Kiner-Falefa is hitting .267 with 19 doubles, two triples, a home run and 17 walks.

Cardinals vs Pirates Head to Head

• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/7/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/6/2025: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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