Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 6

Odds updated as of 8:14 a.m.

In MLB action on Sunday, the Chicago Cubs face the St. Louis Cardinals.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (53-36) vs. St. Louis Cardinals (48-42)
• Date: Sunday, July 6, 2025
• Time: 6:10 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: ESPN

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-200) | STL: (+168)
• Spread: CHC: -1.5 (+102) | STL: +1.5 (-122)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 8-3, 2.65 ERA vs Erick Fedde (Cardinals) - 3-8, 4.56 ERA

The Cubs will give the nod to Matthew Boyd (8-3, 2.65 ERA), who is eyeing win No. 9 on the season, and the Cardinals will counter with Erick Fedde (3-8, 4.56 ERA). Boyd's team is 7-10-0 against the spread in his starts this season. Boyd's team has been victorious in 75% of the games he's started as the moneyline favorite with a record of 9-3. The Cardinals have an 8-8-0 record against the spread in Fedde's starts. The Cardinals are 3-8 in Fedde's 11 starts this season that they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.1%)

Cubs vs Cardinals Moneyline

• The moneyline numbers for Cubs vs. Cardinals reveal Chicago as the favorite (-200) and St. Louis as the underdog (+168) on the road.

Cubs vs Cardinals Spread

• The Cardinals are at the Cubs, and are +1.5 on the runline. The Cardinals are +102 to cover the spread, and the Cubs are -122.

Cubs vs Cardinals Over/Under

• Cubs versus Cardinals on July 6 has an over/under of 7.5 runs, with the odds on the over -112 and the under set at -108.

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Cubs vs Cardinals Betting Trends

• The Cubs have been chosen as favorites in 58 games this year and have walked away with the win 41 times (70.7%) in those games.
• Chicago has a record of 11-1 when favored by -200 or more this year.
• The Cubs and their opponents have gone over the total this season in 47 of their 87 opportunities.
• The Cubs are 43-44-0 against the spread in their 87 games with a line set by sportsbooks this season.
• The Cardinals are 26-24 in games they were the underdog on the moneyline (winning 52% of those games).
• St. Louis has played as a moneyline underdog of +168 or longer in only two games this season, which it lost both.
• In the 89 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 46 times (46-40-3).
• The Cardinals have a 49-40-0 record ATS this season (covering 55.1% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago OPS (.901) this season. He has a .283 batting average, an on-base percentage of .386, and a slugging percentage of .515.
• He is 36th in batting average, seventh in on-base percentage, and 18th in slugging among qualifying batters in baseball.
• Pete Crow-Armstrong has 20 doubles, four triples, 23 home runs and 17 walks. He's batting .270 and slugging .552 with an on-base percentage of .308.
• His batting average ranks 54th among qualified players, his on-base percentage 114th, and his slugging percentage ninth.
• Seiya Suzuki is batting .261 with a .551 slugging percentage and 75 RBI this year.
• Suzuki takes a five-game hitting streak into this matchup. In his last five games he is batting .316 with two doubles, two home runs, three walks and six RBIs.
• Michael Busch leads Chicago with 81 hits, batting .293 this season with 35 extra-base hits.
• Busch has safely hit in two straight games. In his last five games he is batting .550 with a double, four home runs, a walk and seven RBIs.

Cardinals Player Leaders

• Brendan Donovan has accumulated a .367 on-base percentage and a .431 slugging percentage, both team-best numbers for the Cardinals. He's batting .296.
• Including all qualifying players in the majors, his batting average places him 13th, his on-base percentage is 25th, and he is 74th in slugging.
• Donovan hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .278 with a double, a home run, three walks and an RBI.
• Nolan Arenado is hitting .244 with 13 doubles, a triple, 10 home runs and 24 walks. He's slugging .391 with an on-base percentage of .304.
• Including all qualifying players, he ranks 113th in batting average, 117th in on-base percentage and 111th in slugging percentage.
• Alec Burleson has totaled 78 hits, a team-high for the Cardinals.
• Lars Nootbaar has 13 doubles, 11 home runs and 46 walks while hitting .227.

Cubs vs Cardinals Head to Head

• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)

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