Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 4

Odds updated as of 2:12 a.m.

The Chicago Cubs will take on the St. Louis Cardinals in MLB action on Saturday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (49-39) vs. St. Louis Cardinals (46-39)
• Date: Saturday, July 4, 2026
• Time: 8:08 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: FOX

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-162) | STL: (+136)
• Spread: CHC: -1.5 (+136) | STL: +1.5 (-164)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 5-6, 4.30 ERA vs Kyle Leahy (Cardinals) - 6-4, 4.09 ERA

This contest's pitching matchup is set, as the Cubs will send Shota Imanaga (5-6) to the mound, while Kyle Leahy (6-4) will answer the bell for the Cardinals. Imanaga and his team are 5-12-0 ATS this season when he starts. Imanaga's team has been victorious in 46.7% of the games he's started as the moneyline favorite with a record of 7-8. The Cardinals have an 8-7-0 record against the spread in Leahy's starts. The Cardinals have a 4-6 record in Leahy's 10 starts this season when they were the moneyline underdog.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (64.1%)

Cubs vs Cardinals Moneyline

• The moneyline numbers for Cubs vs. Cardinals reveal Chicago as the favorite (-162) and St. Louis as the underdog (+136) on the road.

Cubs vs Cardinals Spread

• The Cubs are hosting the Cardinals and are favored by 1.5 runs (+136 to cover) on the runline. St. Louis is -164 to cover.

Cubs vs Cardinals Over/Under

• The Cubs-Cardinals game on July 4 has been given an over/under of 8.5 runs. The over is set at -110 and the under at -110.

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Cubs vs Cardinals Betting Trends

• The Cubs have won in 33, or 56.9%, of the 58 contests they have been named as odds-on favorites in this year.
• This season Chicago has come away with a win 10 times in 16 chances when named as a favorite of at least -162 on the moneyline.
• The Cubs and their opponents have gone over in 47 of their 86 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 36-50-0 against the spread this season.
• The Cardinals have been the underdog on the moneyline 58 total times this season. They've finished 30-28 in those games.
• When it has played as a moneyline underdog with odds of +136 or longer, St. Louis has a 4-5 record (winning 44.4% of its games).
• The Cardinals have played in 84 games with a set over/under, and have combined with opponents to go over the total 36 times (36-43-5).
• The Cardinals have gone 49-35-0 ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong has 95 hits and an OBP of .374 to go with a slugging percentage of .526. All three of those stats lead Chicago hitters this season. He has a .287 batting average, as well.
• He ranks 23rd in batting average, 20th in on-base percentage, and 14th in slugging among all qualifying batters in MLB.
• Crow-Armstrong hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .375 with a double, two home runs, six walks and four RBIs.
• Nico Hoerner has 22 doubles, four home runs and 35 walks. He's batting .241 and slugging .339 with an on-base percentage of .316.
• Among qualified hitters, he ranks 107th in batting average, 107th in on-base percentage and 144th in slugging percentage.
• Dansby Swanson has collected 59 base hits, an OBP of .298 and a slugging percentage of .428 this season.
• Michael Busch has 11 home runs, 47 RBI and a batting average of .235 this season.
• Busch enters this game on a three-game hitting streak. During his last five outings he is hitting .182 with two home runs, three walks and three RBIs.

Cardinals Player Leaders

• Alec Burleson is hitting .276 with 20 doubles, a triple, 14 home runs and 30 walks. He's slugging .472 with an on-base percentage of .342.
• He ranks 38th in batting average, 58th in on-base percentage and 36th in slugging percentage among all qualified hitters in MLB.
• Jordan Walker's 94 hits and .519 slugging percentage are both team-highs. He has a batting average of .290 with an on-base percentage of .348.
• He is currently 18th in batting average, 50th in on-base percentage and 18th in slugging percentage among all qualifying hitters.
• Ivan Herrera a has .396 on-base percentage to pace the Cardinals.
• JJ Wetherholt is hitting .260 with eight doubles, 12 home runs and 37 walks.

Cubs vs Cardinals Head to Head

• 7/3/2026: 17-1 STL (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/31/2026: 5-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/30/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2026: 6-5 STL (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/28/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)

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