Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 2:12 a.m.

MLB action on Saturday includes the St. Louis Cardinals playing the Chicago White Sox.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (73-75) vs. Chicago White Sox (75-72)
• Date: Saturday, September 12, 2026
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CHSN

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | CHW: (-106)
• Spread: STL: +1.5 (-192) | CHW: -1.5 (+158)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 10-4, 3.41 ERA vs Sean Newcomb (White Sox) - 2-4, 2.71 ERA

The Cardinals will give the nod to Kyle Leahy (10-4, 3.41 ERA), who is eyeing win No. 11 on the season, and the White Sox will counter with Sean Newcomb (2-4, 2.71 ERA). Leahy and his team have a record of 12-13-0 against the spread when he starts. Leahy's team is 5-5 this season when he starts and they are the moneyline favorite. When Newcomb starts, the White Sox are 3-1-0 against the spread. The White Sox have a 2-1 record in Newcomb's three starts this season when they were the underdog on the moneyline.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (56.2%)

Cardinals vs White Sox Moneyline

• Chicago is the underdog, -106 on the moneyline, while St. Louis is a -110 favorite at home.

Cardinals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Cardinals. The White Sox are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs White Sox Over/Under

• The over/under for the Cardinals versus White Sox game on Sept. 12 has been set at 7.5, with -120 odds on the over and -102 odds on the under.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have been chosen as favorites in 48 games this year and have walked away with the win 26 times (54.2%) in those games.
• St. Louis has a record of 25-22 when favored by -110 or more this year.
• The Cardinals and their opponents have gone over the total this season in 66 of their 144 opportunities.
• The Cardinals have an against the spread record of 78-66-0 in 144 games with a line this season.
• The White Sox are 49-53 in games they were listed as the moneyline underdog (winning 48% of those games).
• Chicago is 48-53 (winning 47.5% of its games) when playing as a moneyline underdog of -106 or longer.
• The White Sox have combined with opponents to hit the over on the total 79 times this season for a 79-64-1 record against the over/under.
• The White Sox have collected an 81-63-0 record ATS this season (covering 56.2% of the time).

Cardinals Player Leaders

• Alec Burleson has an OPS of .819, fueled by an OBP of .350 and a team-best slugging percentage of .469 this season. He has a .284 batting average.
• He is 15th in batting average, 43rd in on-base percentage, and 33rd in slugging among all qualified hitters in the majors.
• Jordan Walker leads St. Louis in slugging percentage (.491) and total hits (159) this season. He's batting .283 with an on-base percentage of .338.
• He is 17th in batting average, 56th in on-base percentage and 21st in slugging among qualifying hitters.
• Ivan Herrera leads St. Louis with an OBP of .359 this season while batting .247 with 70 walks and 91 runs scored.
• Nathan Church has been key for St. Louis with 95 hits, an OBP of .292 plus a slugging percentage of .364.
• Church heads into this game on a 10-game hitting streak. During his last 10 games he is hitting .314 with a double, three walks and three RBIs.

White Sox Player Leaders

• Miguel Vargas has totaled 133 hits, a team-best for the White Sox. He's batting .247 and slugging .474 with an on-base percentage of .357.
• Including all the qualifying hitters in MLB, his batting average ranks 81st, his on-base percentage ranks 34th, and he is 29th in slugging.
• Chase Meidroth is slugging .402 to lead his team. He has a batting average of .269 with an on-base percentage of .345.
• Including all qualifying hitters, he is 44th in batting average, 47th in on-base percentage and 90th in slugging percentage.
• Sam Antonacci has a team-best .365 on-base percentage.
• Tristan Peters is batting .279 with 30 doubles, four triples, 12 home runs and 34 walks.

Cardinals vs White Sox Head to Head

• 9/11/2026: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/19/2025: 8-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/19/2025: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2023: 8-7 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)

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