Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 12:12 a.m.

The Saturday slate in MLB includes a matchup between the San Diego Padres and the San Francisco Giants.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Giants Game Info

• San Diego Padres (78-68) vs. San Francisco Giants (62-85)
• Date: Saturday, September 12, 2026
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-156) | SF: (+132)
• Spread: SD: -1.5 (+114) | SF: +1.5 (-134)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 10-9, 3.00 ERA vs César Perdomo (Giants) - 0-0, 0.90 ERA

The probable starters are Michael King (10-9) for the Padres and Cesar Perdomo for the Giants. King's team is 11-18-0 against the spread this season in his starts. King's team has won 47.4% of his starts when they are favored on the moneyline (9-10). Perdomo has started only one game with a set spread, which the Giants failed to cover. The Giants were the moneyline underdog for one Perdomo start this season -- they lost.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (50.9%)

Padres vs Giants Moneyline

• San Francisco is the underdog, +132 on the moneyline, while San Diego is a -156 favorite despite being on the road.

Padres vs Giants Spread

• The Giants are hosting the Padres, and are +1.5 on the runline. The Giants are +114 to cover the spread, and the Padres are -134.

Padres vs Giants Over/Under

• The over/under for the Padres versus Giants game on Sept. 12 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have been victorious in 39, or 57.4%, of the 68 contests they have been chosen as favorites in this season.
• This year San Diego has won 12 of 19 games when listed as at least -156 on the moneyline.
• The Padres and their opponents have gone over the total this season in 64 of their 146 opportunities.
• The Padres are 84-62-0 against the spread in their 146 games that had a posted line this season.
• The Giants have won 37 of the 98 games they were listed as the moneyline underdog this season (37.8%).
• When it has played as a moneyline underdog with odds of +132 or longer, San Francisco has a record of 14-19 (42.4%).
• In the 144 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 69 times (69-65-10).
• The Giants have a 69-75-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 161 hits and an OBP of .351, plus a team-best slugging percentage of .449. He's batting .284.
• Among qualified hitters in the majors, his batting average ranks 15th, his on-base percentage ranks 41st, and he is 47th in slugging.
• Manny Machado has 22 doubles, 26 home runs and 71 walks. He's batting .224 and slugging .414 with an on-base percentage of .314.
• He ranks 120th in batting average, 95th in on-base percentage and 79th in slugging in MLB.
• Jackson Merrill is batting .245 with a .431 slugging percentage and 79 RBI this year.
• Ty France has been key for San Diego with 114 hits, an OBP of .363 plus a slugging percentage of .510.
• France enters this matchup on a two-game hitting streak. During his last five outings he is batting .278 with a double, two walks and an RBI.

Giants Player Leaders

• Rafael Devers has 142 hits with a .340 on-base percentage and a .518 slugging percentage, all club-bests for the Giants. He's batting .258.
• He ranks 66th in batting average, 54th in on-base percentage and ninth in slugging percentage among all qualifying hitters in the majors.
• Jung Hoo Lee leads his team with a .408 slugging percentage. He has a batting average of .281 with an on-base percentage of .324.
• Including all qualifying players, his batting average places him 22nd, his on-base percentage is 78th, and he is 84th in slugging.
• Bryce Eldridge is hitting .268 with 21 doubles, 16 home runs and 55 walks.
• Drew Gilbert is batting .232 with 14 doubles, three triples, eight home runs and 34 walks.

Padres vs Giants Head to Head

• 8/2/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/1/2026: 6-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 7/31/2026: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 7/30/2026: 4-1 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/6/2026: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: -106)
• 5/5/2026: 10-5 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)

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