Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 6

Odds updated as of 10:11 p.m.

The St. Louis Cardinals versus the Cincinnati Reds is on the MLB schedule for Saturday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Reds Game Info

• St. Louis Cardinals (32-28) vs. Cincinnati Reds (31-30)
• Date: Saturday, June 6, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Reds.TV

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-142) | CIN: (+120)
• Spread: STL: -1.5 (+142) | CIN: +1.5 (-176)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 3-3, 4.35 ERA vs Nick Lodolo (Reds) - 2-1, 5.20 ERA

The Cardinals will call on Matthew Liberatore (3-3) against the Reds and Nick Lodolo (2-1). Liberatore's team is 7-5-0 against the spread in his starts this season. Liberatore's team is 2-0 this season when he starts and they're favored on the moneyline. The Reds have gone 3-2-0 ATS in Lodolo's five starts with a set spread. The Reds have been the underdog on the moneyline in three of Lodolo's starts this season, and they went 2-1 in those games.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51%)

Cardinals vs Reds Moneyline

• St. Louis is the favorite, -142 on the moneyline, while Cincinnati is a +120 underdog on the road.

Cardinals vs Reds Spread

• The Reds are +1.5 on the spread (-176 to cover), and St. Louis is +142 to cover the runline.

Cardinals vs Reds Over/Under

• The Cardinals-Reds game on June 6 has been given an over/under of 9.5 runs. The over is set at +102 and the under at -124.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have been chosen as favorites in 11 games this year and have walked away with the win six times (54.5%) in those games.
• These are the best odds of a victory sportsbooks have given St. Louis this season, with a -142 moneyline set for this game.
• The Cardinals and their opponents have gone over in 25 of their 59 games with a total set by sportsbooks this season.
• The Cardinals are 35-24-0 against the spread in their 59 games with a line set by sportsbooks this season.
• The Reds have been the underdog on the moneyline 37 total times this season. They've gone 20-17 in those games.
• When playing as a moneyline underdog with odds of +120 or longer, Cincinnati has gone 4-7 (36.4%).
• The Reds have had an over/under set by oddsmakers 59 times, and have combined with opponents to go over the total in 36 of those games (36-22-1).
• The Reds have collected a 33-26-0 record ATS this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis in slugging percentage (.537) and total hits (66) this season. He's batting .291 with an on-base percentage of .355.
• Among qualified hitters in baseball, he is 23rd in batting average, 46th in on-base percentage, and 12th in slugging.
• Walker hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .238 with two RBIs.
• Alec Burleson leads St. Louis in slugging percentage (.443) thanks to 22 extra-base hits. He's batting .287 with an on-base percentage of .352.
• He ranks 27th in batting average, 51st in on-base percentage and 62nd in slugging in the majors.
• Burleson heads into this matchup looking to extend his five-game hit streak. During his last five outings he is hitting .400 with two doubles, a walk and seven RBIs.
• JJ Wetherholt has collected 56 base hits, an OBP of .357 and a slugging percentage of .400 this season.
• Ivan Herrera has 58 hits this season and a team-best OBP of .382.
• Herrera brings a two-game hitting streak into this game. In his last five games he is hitting .200 with a walk.

Reds Player Leaders

• Sal Stewart is batting .258 with 12 doubles, 12 home runs and 33 walks. He's slugging .467 with an on-base percentage of .351.
• He ranks 66th in batting average, 54th in on-base percentage and 45th in slugging percentage among all qualified hitters in MLB.
• Spencer Steer's .353 OBP leads his team. He has a batting average of .278 while slugging .464.
• He ranks 43rd in batting average, 49th in on-base percentage and 46th in slugging percentage in MLB.
• JJ Bleday is batting .289 with eight doubles, a triple, 10 home runs and 19 walks.
• Nathaniel Lowe is hitting .250 with nine doubles, nine home runs and 16 walks.

Cardinals vs Reds Head to Head

• 5/23/2026: 7-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2026: 8-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/17/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)

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