Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 2:11 a.m.

Saturday's slate in the MLB includes a matchup between the St. Louis Cardinals and the Washington Nationals.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (20-19) vs. Washington Nationals (17-22)
• Date: Saturday, May 10, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSMW

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-118) | WSH: (-100)
• Spread: STL: -1.5 (+140) | WSH: +1.5 (-170)
• Total: 9 -- Over: (-108) | Under: (-112)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 2-2, 4.75 ERA vs Trevor Williams (Nationals) - 2-3, 5.86 ERA

This contest's pitching matchup is set, as the Cardinals will send Andre Pallante (2-2) to the mound, while Trevor Williams (2-3) will take the ball for the Nationals. Pallante and his team are 4-3-0 ATS this season when he starts. Pallante has yet to start a game this season when his team was the moneyline favorite. The Nationals have a 5-2-0 record against the spread in Williams' starts. The Nationals have a 3-4 record in Williams' seven starts this season when they were the moneyline underdog.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.9%)

Cardinals vs Nationals Moneyline

• Looking at the moneyline for Cardinals-Nationals, St. Louis is the favorite at -118, and Washington is -100 playing at home.

Cardinals vs Nationals Spread

• The Cardinals are favored by 1.5 runs on the road versus the Nationals. The Cardinals are +140 to cover the spread, while the Nationals are -170.

Cardinals vs Nationals Over/Under

• Cardinals versus Nationals, on May 10, has an over/under of 9, with the over being -108 and the under -112.

Bet on St. Louis Cardinals vs. Washington Nationals on FanDuel today!

Cardinals vs Nationals Betting Trends

• The Cardinals have been victorious in six, or 50%, of the 12 contests they have been chosen as favorites in this season.
• St. Louis has a record of 5-3 in contests when oddsmakers favor them by -118 or more on the moneyline.
• The Cardinals and their opponents have hit the over in 22 of their 39 games with a total set by oddsmakers this season.
• The Cardinals are 20-19-0 against the spread in their 39 games with a line set by sportsbooks this season.
• The Nationals have won 14 of the 28 games they were the moneyline underdog this season (50%).
• When playing as a moneyline underdog with odds of -100 or longer, Washington has gone 12-12 (50%).
• The Nationals have had an over/under set by oddsmakers 37 times, and have combined with opponents to go over the total in 21 of those games (21-16-0).
• The Nationals have collected a 20-17-0 record ATS this season (covering 54.1% of the time).

Cardinals Player Leaders

• Lars Nootbaar is batting .245 with eight doubles, five home runs and 29 walks. He has an on-base percentage of .373 and a slugging percentage of .401.
• Among all qualifying hitters, he ranks 92nd in batting average, his on-base percentage ranks 34th, and he is 91st in slugging.
• Nootbaar has picked up at least one hit in two games in a row. In his last five games he is batting .250 with two doubles, four walks and an RBI.
• Brendan Donovan has 47 hits and an OBP of .386 to go with a slugging percentage of .469. All three of those stats lead St. Louis hitters this season. He's batting .329.
• Among qualifying hitters, his batting average places him sixth, his on-base percentage 17th, and his slugging percentage 39th.
• Donovan has picked up a hit in nine straight games. In his last 10 games he is batting .270 with two doubles, five walks and three RBIs.
• Nolan Arenado is batting .269 with a .403 slugging percentage and 14 RBI this year.
• Arenado brings a five-game hitting streak into this game. During his last five outings he is hitting .450 with two walks and an RBI.
• Victor Scott II is batting .291 with a .361 OBP and 16 RBI for St. Louis this season.
• Scott heads into this matchup on a nine-game hitting streak. In his last 10 games he is hitting .367 with a double, a home run, six walks and six RBIs.

Nationals Player Leaders

• James Wood has a team-best OBP (.379) and slugging percentage (.547), while pacing the Nationals in hits (42, while batting .280).
• Including all the qualified hitters in MLB, his batting average puts him 38th, his on-base percentage ranks 24th, and he is 13th in slugging.
• Wood heads into this game on an eight-game hitting streak. During his last 10 games he is hitting .341 with four doubles, a home run, six walks and three RBIs.
• C.J. Abrams is batting .304 with six doubles, two triples, four home runs and eight walks. He's slugging .520 with an on-base percentage of .368.
• Nathaniel Lowe has seven doubles, six home runs and 17 walks while hitting .248.
• Luis Garcia is hitting .230 with five doubles, three home runs and 10 walks.

Cardinals vs Nationals Head to Head

• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/26/2024: 10-8 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/8/2024: 6-0 STL (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/7/2024: 8-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/6/2024: 14-6 WSH (Favorite: Nationals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/5/2024: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/16/2023: 8-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/15/2023: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)

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