Cardinals vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 10:12 a.m.

Wednesday's slate in the MLB includes a matchup between the St. Louis Cardinals and the Athletics.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cardinals vs Athletics Game Info

• St. Louis Cardinals (69-71) vs. Athletics (64-76)
• Date: Wednesday, September 3, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and NBCS-CA

Cardinals vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | OAK: (-104)
• Spread: STL: +1.5 (-188) | OAK: -1.5 (+155)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cardinals vs Athletics Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 6-11, 4.32 ERA vs Jeffrey Springs (Athletics) - 10-9, 4.17 ERA

The Cardinals will give the nod to Matthew Liberatore (6-11, 4.32 ERA), who is eyeing win No. 7 on the season, and the Athletics will turn to Jeffrey Springs (10-9, 4.17 ERA). Liberatore's team is 12-11-0 against the spread this season in his starts. Liberatore's team has been victorious in 30.8% of the games he's started as the moneyline favorite with a record of 4-9. The Athletics are 14-12-0 ATS in Springs' 26 starts that had a set spread. The Athletics have been the underdog on the moneyline in 17 of Springs' starts this season, and they went 11-6 in those games.

Cardinals vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.2%)

Cardinals vs Athletics Moneyline

• The Cardinals vs Athletics moneyline has the Cardinals as a -112 favorite, while the Athletics are a -104 underdog on the road.

Cardinals vs Athletics Spread

• The Cardinals are hosting the Athletics and are 1.5 on the runline and -188 to cover, while Sacramento is +155 to cover the spread.

Cardinals vs Athletics Over/Under

• The over/under for Cardinals-Athletics on Sept. 3 is 8.5. The over is -115, and the under is -105.

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Cardinals vs Athletics Betting Trends

• The Cardinals have been victorious in 30, or 50%, of the 60 contests they have been chosen as favorites in this season.
• This year, the Cardinals have won 29 of 57 games when listed as at least -112 or better on the moneyline.
• The Cardinals and their opponents have hit the over in 70 of their 134 games with a total this season.
• The Cardinals are 68-66-0 against the spread in their 134 games that had a posted line this season.
• The Athletics are 46-58 in games they were listed as the moneyline underdog (winning 44.2% of those games).
• When they have played as a moneyline underdog with odds of -104 or longer, the Athletics have gone 44-57 (43.6%).
• The Athletics have combined with their opponents to go over the total 70 times this season for a 70-63-6 record against the over/under.
• The Athletics have collected a 73-66-0 record ATS this season (covering 52.5% of the time).

Cardinals Player Leaders

• Willson Contreras is batting .249 with 30 doubles, 20 home runs and 42 walks. He has an on-base percentage of .335 and a slugging percentage of .441.
• Among qualifying batters in the majors, he is 98th in batting average, 65th in on-base percentage, and 71st in slugging.
• Masyn Winn is batting .254 with 27 doubles, nine home runs and 32 walks, while slugging .368 with an on-base percentage of .309.
• Among all qualified hitters, he is 88th in batting average, 115th in on-base percentage and 139th in slugging percentage.
• Lars Nootbaar has 106 hits this season and has a slash line of .244/.333/.389.
• Nootbaar enters this game with four games in a row with at least one hit. In his last five games he is hitting .364 with a double and a triple.
• Ivan Herrera has 13 home runs, 53 RBI and a batting average of .287 this season.
• Herrera has safely hit in eight straight games. In his last 10 outings he is hitting .303 with a double, three home runs, five walks and six RBIs.

Athletics Player Leaders

• Brent Rooker has put up a team-best .492 slugging percentage. He's batting .268 with an on-base percentage of .339.
• Including all qualifying hitters in the big leagues, he ranks 50th in batting average, 57th in on-base percentage and 29th in slugging percentage.
• Tyler Soderstrom is hitting .271 with 28 doubles, a triple, 23 home runs and 51 walks. He's slugging .468 with an on-base percentage of .343.
• Including all qualified hitters, he is 42nd in batting average, 49th in on-base percentage and 45th in slugging percentage.
• Nick Kurtz is batting .309 with 24 doubles, two triples, 27 home runs and 54 walks.
• Shea Langeliers has 106 hits to lead his team.

Cardinals vs Athletics Head to Head

• 9/2/2025: 2-1 STL (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/1/2025: 11-3 OAK (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/17/2024: 6-3 OAK (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2024: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/15/2024: 3-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/16/2023: 8-0 OAK (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/15/2023: 6-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/14/2023: 7-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +198)

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