Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 5:17 a.m.

The Milwaukee Brewers will face the St. Louis Cardinals in MLB action on Saturday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (90-58) vs. St. Louis Cardinals (72-76)
• Date: Saturday, September 13, 2025
• Time: 8:15 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FOX

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-174) | STL: (+146)
• Spread: MIL: -1.5 (+132) | STL: +1.5 (-160)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 5-2, 4.09 ERA vs Sonny Gray (Cardinals) - 13-8, 4.45 ERA

The Brewers will give the ball to Jacob Misiorowski (5-2, 4.09 ERA), who is eyeing win No. 6 on the season, and the Cardinals will turn to Sonny Gray (13-8, 4.45 ERA). Misiorowski and his team are 8-4-0 ATS this season when he starts. Misiorowski's team has won 50% of his starts when they are favored on the moneyline (3-3). When Gray starts, the Cardinals are 13-14-0 against the spread. The Cardinals have a 5-3 record in Gray's eight starts this season when they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (58.1%)

Brewers vs Cardinals Moneyline

• St. Louis is a +146 underdog on the moneyline, while Milwaukee is a -174 favorite at home.

Brewers vs Cardinals Spread

• The Brewers are hosting the Cardinals and are favored by 1.5 runs on the spread. The Brewers are +132 to cover the runline, with the Cardinals being -160.

Brewers vs Cardinals Over/Under

• The Brewers-Cardinals contest on Sept. 13 has been given an over/under of 7.5 runs. The over is set at -115 and the under at -105.

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Brewers vs Cardinals Betting Trends

• The Brewers have been favorites in 83 games this season and have come away with the win 54 times (65.1%) in those contests.
• This season Milwaukee has come away with a win 14 times in 17 chances when named as a favorite of at least -174 on the moneyline.
• Contests with the Brewers have gone over the total set by sportsbooks in 73 of 145 chances this season.
• In 145 games with a line this season, the Brewers have a mark of 82-63-0 against the spread.
• The Cardinals have been the underdog on the moneyline 78 total times this season. They've finished 37-41 in those games.
• St. Louis has a record of 3-13 when playing as a moneyline underdog with odds of +146 or longer (18.8%).
• In the 142 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 73 times (73-64-5).
• The Cardinals have covered 49.3% of their games this season, going 70-72-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee with a slugging percentage of .443, fueled by 45 extra-base hits. He has a .289 batting average and an on-base percentage of .355.
• Among the qualifying hitters in baseball, his batting average ranks 14th, his on-base percentage ranks 30th, and he is 64th in slugging.
• Turang hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .227 with a home run, two walks and three RBIs.
• William Contreras is hitting .261 with 26 doubles, 17 home runs and 79 walks, while slugging .405 with an on-base percentage of .357.
• Among all qualifying players, he is 69th in batting average, 23rd in on-base percentage and 97th in slugging percentage.
• Christian Yelich is batting .267 with a .464 slugging percentage and 95 RBI this year.
• Jackson Chourio has 137 hits, which is tops among Milwaukee hitters this season, while batting .281 with 57 extra-base hits.
• Chourio has safely hit in five games in a row. During his last five outings he is batting .400 with two doubles, two home runs, two walks and five RBIs.

Cardinals Player Leaders

• Alec Burleson has accumulated a slugging percentage of .455 and has 127 hits, both team-best numbers for the Cardinals. He's batting .283 and with an on-base percentage of .334.
• Including all the qualified hitters in the majors, his batting average ranks 19th, his on-base percentage is 62nd, and he is 52nd in slugging.
• Willson Contreras is batting .254 with 30 doubles, a triple, 20 home runs and 43 walks. He's slugging .443 with an on-base percentage of .338.
• Including all qualifying hitters, he is 88th in batting average, 54th in on-base percentage and 64th in slugging percentage.
• Brendan Donovan has accumulated an on-base percentage of .347, a team-best for the Cardinals.
• Masyn Winn has 27 doubles, nine home runs and 34 walks while hitting .253.

Brewers vs Cardinals Head to Head

• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2024: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2024: 7-4 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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