Blue Jays vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 2:12 a.m.

The Toronto Blue Jays are among the MLB squads playing on Monday, versus the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Blue Jays vs Astros Game Info

• Toronto Blue Jays (38-39) vs. Houston Astros (37-42)
• Date: Monday, June 22, 2026
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and SCHN

Blue Jays vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-126) | HOU: (+108)
• Spread: TOR: -1.5 (+176) | HOU: +1.5 (-215)
• Total: 7 -- Over: (-118) | Under: (-104)

Blue Jays vs Astros Probable Starting Pitchers

Probable Pitchers: Shane Bieber (Blue Jays) - 0-0, 0.00 ERA vs Hunter Brown (Astros) - 1-0, 1.10 ERA

The Blue Jays will call on Shane Bieber versus the Astros and Hunter Brown (1-0). Bieber and his team were 6-5-0 ATS in his 11 appearances with a spread last season. Bieber and his team had a 6-2 record when he pitched as a favorite last season. When Brown starts, the Astros are 2-1-0 against the spread. The Astros have yet to be named a moneyline underdog when Brown starts this season.

Blue Jays vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54%)

Blue Jays vs Astros Moneyline

• Looking at the moneyline for Astros-Blue Jays, Houston is the underdog at +108, and Toronto is -126 playing at home.

Blue Jays vs Astros Spread

• The Blue Jays are favored by 1.5 runs at home against the Astros. The Blue Jays are +176 to cover the spread, while the Astros are -215.

Blue Jays vs Astros Over/Under

• A combined run total of 7 has been set for Blue Jays-Astros on June 22, with the over at -118 and the under at -104.

Bet on Toronto Blue Jays vs. Houston Astros on FanDuel today!

Blue Jays vs Astros Betting Trends

• The Blue Jays have been chosen as favorites in 40 games this year and have walked away with the win 24 times (60%) in those games.
• This year Toronto has won 14 of 25 games when listed as at least -126 on the moneyline.
• The Blue Jays and their opponents have gone over in 40 of their 76 games with a total set by sportsbooks this season.
• In 76 games with a line this season, the Blue Jays have a mark of 38-38-0 against the spread.
• The Astros have been the moneyline underdog 48 total times this season. They've finished 23-25 in those games.
• Houston has an 18-18 record (winning 50% of its games) when it has played as a moneyline underdog of +108 or longer.
• The Astros have combined with opponents to go over the total 42 times this season for a 42-34-3 record against the over/under.
• The Astros have gone 36-43-0 ATS this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .365 this season while batting .279 with 34 walks and 42 runs scored. He has a slugging percentage of .370.
• Among qualifying batters in MLB, his batting average ranks 37th, his on-base percentage ranks 36th, and he is 120th in slugging.
• Ernie Clement has hit seven homers this season while driving in 28 runs. He's batting .292 this season and slugging .440 with an on-base percentage of .311.
• Among qualifiers, he is 17th in batting average, 114th in on-base percentage and 69th in slugging percentage.
• Kazuma Okamoto has 62 hits and is batting .229 this season.
• Daulton Varsho has six home runs, 20 RBI and a batting average of .256 this season.

Astros Player Leaders

• Yordan Alvarez has a team-high OBP (.428) and slugging percentage (.640), and paces the Astros in hits (91, while batting .322).
• Including all qualified hitters in MLB, he is fourth in batting average, second in on-base percentage and first in slugging percentage.
• Christian Walker has 14 doubles, a triple, 18 home runs and 27 walks while hitting .241. He's slugging .481 with an on-base percentage of .313.
• Including all qualifying hitters, his batting average puts him 103rd, his on-base percentage ranks 107th, and he is 35th in slugging.
• Isaac Paredes has 14 doubles, 10 home runs and 30 walks while hitting .246.
• Jeremy Pena is hitting .283 with nine doubles, six home runs and 12 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!