Astros vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 18

Odds updated as of 7:11 p.m.

MLB action on Friday includes the Houston Astros playing the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Padres Game Info

• Houston Astros (8-10) vs. San Diego Padres (15-4)
• Date: Friday, April 18, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and SDPA

Astros vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | SD: (+136)
• Spread: HOU: -1.5 (+130) | SD: +1.5 (-156)
• Total: 9 -- Over: (-102) | Under: (-120)

Astros vs Padres Probable Starting Pitchers

Probable Pitchers: Ryan Gusto (Astros) - 1-1, 3.00 ERA vs Kyle Hart (Padres) - 2-0, 5.40 ERA

The Astros will give the ball to Ryan Gusto (1-1, 3.00 ERA), who is eyeing win No. 2 on the season, and the Padres will turn to Kyle Hart (2-0, 5.40 ERA). Gusto and his team failed to cover the spread in his only opportunity this season as a starter. Gusto's team lost his only start as a favorite this season. In each of Hart's three starts that had a set spread, the Padres covered. The Padres were the underdog on the moneyline for one Hart start this season -- they won.

Astros vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.4%)

Astros vs Padres Moneyline

• Looking at the moneyline for Padres-Astros, San Diego is the underdog at +136, and Houston is -162 playing at home.

Astros vs Padres Spread

• The Padres are at the Astros, and are +1.5 on the runline. The Padres are +130 to cover the spread, and the Astros are -156.

Astros vs Padres Over/Under

• The over/under for Astros-Padres on April 18 is 9. The over is -102, and the under is -120.

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Astros vs Padres Betting Trends

• The Astros have won in five, or 45.5%, of the 11 contests they have been named as odds-on favorites in this year.
• This season Houston has been victorious one time in three chances when named as a favorite of at least -162 on the moneyline.
• The Astros and their opponents have gone over the total this season in seven of their 18 opportunities.
• The Astros have an against the spread mark of 8-10-0 in 18 games with a line this season.
• The Padres have a 4-3 record in games they were listed as the moneyline underdog (winning 57.1% of those games).
• San Diego has played as a moneyline underdog of +136 or longer in only one game this season, which it lost.
• In the 19 games oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total eight times (8-10-1).
• The Padres have gone 14-5-0 against the spread this season.

Astros Player Leaders

• Jose Carlos Altuve leads Houston in slugging percentage (.446) and total hits (23) this season. He's batting .311 with an on-base percentage of .342.
• Among qualifying batters, he is 24th in batting average, his on-base percentage ranks 64th, and he is 67th in slugging.
• Altuve will look for his third straight game with a hit in this matchup. During his last five outings he is hitting .167 with a double and an RBI.
• Jeremy Pena is batting .215 with two doubles, three home runs and six walks. He's slugging .385 with an on-base percentage of .297.
• He ranks 114th in batting average, 117th in on-base percentage and 96th in slugging among qualified batters.
• Pena has picked up at least one hit in eight games in a row. During his last 10 outings he is hitting .237 with two doubles, a home run, four walks and five RBI.
• Isaac Paredes leads Houston with an OBP of .350 this season while batting .235 with 10 walks and eight runs scored.
• Yordan Ruben Alvarez is batting .224 with a .333 OBP and 10 RBI for Houston this season.

Padres Player Leaders

• Fernando Tatis Jr. has a team-high OBP (.425) and slugging percentage (.623), while pacing the Padres in hits (24, while batting .348).
• Including all qualifying players, he is fifth in batting average, while his on-base percentage is ninth and he is 10th in slugging.
• Tatis takes a six-game hitting streak into this game. In his last 10 games he is batting .282 with five home runs, six walks and nine RBI.
• Manny Machado is batting .324 with eight doubles, two home runs and eight walks. He's slugging .521 with an on-base percentage of .392.
• Including all qualifying hitters, his batting average places him 12th, his on-base percentage is 22nd, and he is 32nd in slugging.
• Luis Sangel (Reveron) Arraez is hitting .275 with three doubles, two home runs and three walks.
• Xander Bogaerts is hitting .258 with six doubles and 10 walks.

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