Astros vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 15

Odds updated as of 7:11 p.m.

The MLB's Tuesday schedule includes the Houston Astros facing the St. Louis Cardinals.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Cardinals Game Info

• Houston Astros (7-9) vs. St. Louis Cardinals (8-8)
• Date: Tuesday, April 15, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMWX and SCHN

Astros vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-134) | STL: (+114)
• Spread: HOU: -1.5 (+132) | STL: +1.5 (-160)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Astros vs Cardinals Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 1-1, 2.00 ERA vs Erick Fedde (Cardinals) - 1-1, 4.20 ERA

The probable starters are Hunter Brown (1-1) for the Astros and Erick Fedde (1-1) for the Cardinals. Brown's team is 1-2-0 against the spread this season in his starts. Brown's team is 0-2 this season when he starts and they're favored on the moneyline. The Cardinals have a 1-2-0 record against the spread in Fedde's starts. The Cardinals were the moneyline underdog for two Fedde starts this season -- they split the games.

Astros vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (50.4%)

Astros vs Cardinals Moneyline

• Looking at the moneyline for Astros-Cardinals, Houston is the favorite at -134, and St. Louis is +114 playing at home.

Astros vs Cardinals Spread

• The Astros are 1.5-run road favorites on the runline against the Cardinals. The Astros are +132 to cover, and the Cardinals are -160.

Astros vs Cardinals Over/Under

• Astros versus Cardinals, on April 15, has an over/under of 7.5, with the over being -104 and the under -118.

Bet on Houston Astros vs. St. Louis Cardinals on FanDuel today!

Astros vs Cardinals Betting Trends

• The Astros have been victorious in four of the 10 contests they have been chosen as favorites in this season.
• Houston has a record of 2-3 in contests when bookmakers favor them by -134 or more on the moneyline.
• The Astros and their opponents have gone over in seven of their 16 games with a total set by sportsbooks this season.
• In 16 games with a line this season, the Astros have a mark of 7-9-0 against the spread.
• The Cardinals have gone 7-4 in games they were the underdog on the moneyline (winning 63.6% of those games).
• St. Louis is 2-1 (winning 66.7% of its games) when playing as a moneyline underdog of +114 or longer.
• The Cardinals have combined with opponents to go over the total 10 times this season for a 10-5-1 record against the over/under.
• The Cardinals have put together an 8-8-0 record ATS this season (covering 50% of the time).

Astros Player Leaders

• Jose Altuve leads Houston with a slugging percentage of .424, fueled by three extra-base hits. He has a .288 batting average and an on-base percentage of .324.
• Among all qualifying batters in baseball, he ranks 47th in batting average, 83rd in on-base percentage, and 81st in slugging.
• Isaac Paredes leads Houston with 16 hits and an OBP of .375 this season. He's batting .262 and slugging .426.
• His batting average ranks 68th among qualified players, his on-base percentage 42nd, and his slugging percentage 78th.
• Jeremy Pena has collected 12 base hits, an OBP of .288 and a slugging percentage of .379 this season.
• Pena has recorded at least one base hit in six straight games. In his last 10 outings he is hitting .256 with a double, two home runs, three walks and six RBI.
• Yordan Alvarez is batting .222 with a .338 OBP and nine RBI for Houston this season.

Cardinals Player Leaders

• Nolan Arenado is batting .316 with six doubles, two home runs and nine walks. He's slugging .526 with an on-base percentage of .409.
• Including all qualifying players, he ranks 24th in batting average, while his on-base percentage is 19th and he is 37th in slugging.
• Brendan Donovan has racked up 25 hits with a .420 OBP while slugging .563. Those stats all lead his team. He also has a batting average of .391.
• Including all qualifying hitters, his batting average puts him second, his on-base percentage is 14th, and he is 19th in slugging.
• Lars Nootbaar is batting .279 with two doubles, two home runs and 12 walks.
• Victor Scott II is hitting .259 with two doubles, a triple, a home run and six walks.

Astros vs Cardinals Head to Head

• 4/14/2025: 8-3 STL (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2024: 4-2 STL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/4/2024: 8-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/3/2024: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/29/2023: 14-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/28/2023: 10-7 HOU (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/27/2023: 4-2 STL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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