Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 15

Odds updated as of 9:11 p.m.

In MLB action on Tuesday, the San Diego Padres play the Chicago Cubs.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cubs Game Info

• San Diego Padres (14-3) vs. Chicago Cubs (11-8)
• Date: Tuesday, April 15, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MARQ

Padres vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-122) | CHC: (+104)
• Spread: SD: +1.5 (-205) | CHC: -1.5 (+168)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Padres vs Cubs Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 1-1, 1.72 ERA vs Shota Imanaga (Cubs) - 2-1, 2.70 ERA

The Padres will give the nod to Randy Vasquez (1-1, 1.72 ERA), who is eyeing win No. 2 on the season, and the Cubs will turn to Shota Imanaga (2-1, 2.70 ERA). Vasquez and his team are 2-1-0 ATS this season when he starts. This will be Vasquez's first start this season with his team as the moneyline favorite. When Imanaga starts, the Cubs have gone 2-2-0 against the spread. The Cubs were the moneyline underdog for two Imanaga starts this season -- they split the games.

Padres vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (51.5%)

Padres vs Cubs Moneyline

• Chicago is a +104 underdog on the moneyline, while San Diego is a -122 favorite at home.

Padres vs Cubs Spread

• The Cubs are 1.5-run favorites against the spread for this matchup with the Padres. The Cubs are +168 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Cubs Over/Under

• Padres versus Cubs, on April 15, has an over/under of 7.5, with the over being -120 and the under -102.

Bet on San Diego Padres vs. Chicago Cubs on FanDuel today!

Padres vs Cubs Betting Trends

• The Padres have been chosen as favorites in 11 games this year and have walked away with the win 10 times (90.9%) in those games.
• San Diego has a record of 10-1 when favored by -122 or more this year.
• The Padres and their opponents have gone over in eight of their 17 games with a total set by sportsbooks this season.
• The Padres have posted a record of 12-5-0 against the spread this season.
• The Cubs have been the moneyline underdog 11 total times this season. They've gone 5-6 in those games.
• When it has played as a moneyline underdog with odds of +104 or longer, Chicago has a record of 3-5 (37.5%).
• The Cubs have combined with opponents to hit the over on the total 13 times this season for a 13-5-1 record against the over/under.
• The Cubs have covered 57.9% of their games this season, going 11-8-0 against the spread.

Padres Player Leaders

• Fernando Tatis Jr. has 22 hits and an OBP of .429 to go with a slugging percentage of .672. All three of those stats are tops among San Diego hitters this season. He has a .361 batting average, as well.
• He ranks ninth in batting average, 10th in on-base percentage, and sixth in slugging among all qualified hitters in MLB.
• Tatis has recorded a base hit in four games in a row. During his last five outings he is batting .316 with four home runs, two walks and five RBI.
• Manny Machado is batting .317 with seven doubles, a home run and eight walks, while slugging .476 with an on-base percentage of .394.
• He is 22nd in batting average, 30th in on-base percentage and 55th in slugging in the majors.
• Machado enters this game looking to extend his two-game hit streak. During his last five outings he is batting .313 with two doubles, five walks and an RBI.
• Luis Arraez has collected 20 base hits, an OBP of .307 and a slugging percentage of .408 this season.
• Arraez takes a three-game hitting streak into this matchup. During his last five outings he is hitting .217 with a double, a home run and an RBI.
• Xander Bogaerts has been key for San Diego with 17 hits, an OBP of .386 plus a slugging percentage of .373.

Cubs Player Leaders

• Kyle Tucker has accumulated a team-best OBP (.429) and slugging percentage (.613). He's batting .307.
• Including all the qualified hitters in the big leagues, his batting average ranks 31st, his on-base percentage ranks 10th, and he is 13th in slugging.
• Carson Kelly has a double, a triple, four home runs and 11 walks while hitting .417. He's slugging 1.042 with an on-base percentage of .595.
• Seiya Suzuki is batting .292 with two doubles, a triple, four home runs and 11 walks.
• Michael Busch has collected 18 hits to lead his team.

Padres vs Cubs Head to Head

• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/10/2024: 10-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/9/2024: 5-1 CHC (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/8/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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