Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 6:12 a.m.

In MLB action on Wednesday, the Houston Astros face the Athletics.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Astros vs Athletics Game Info

• Houston Astros (84-73) vs. Athletics (74-83)
• Date: Wednesday, September 24, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-146) | OAK: (+124)
• Spread: HOU: -1.5 (+112) | OAK: +1.5 (-134)
• Total: 9 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 12-8, 2.30 ERA vs Luis Severino (Athletics) - 7-11, 4.72 ERA

The Astros will give the nod to Hunter Brown (12-8, 2.30 ERA), who is eyeing win No. 13 on the season, and the Athletics will turn to Luis Severino (7-11, 4.72 ERA). Brown and his team are 17-13-0 ATS this season when he starts. Brown's team has been victorious in 59.1% of the games he's started as the moneyline favorite with a record of 13-9. When Severino starts, the Athletics are 12-15-0 against the spread. The Athletics have a 9-13 record in Severino's 22 starts this season when they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -146 favorite, while the Athletics are a +124 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +112 to cover, while the Athletics are -134 to cover.

Astros vs Athletics Over/Under

• The Astros-Athletics game on Sept. 24 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

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Astros vs Athletics Betting Trends

• The Astros have been favorites in 94 games this season and have come away with the win 50 times (53.2%) in those contests.
• This season, the Astros have come away with a win 20 times in 36 chances when named as a favorite of at least -146 or better on the moneyline.
• The Astros and their opponents have hit the over in 71 of their 156 games with a total this season.
• In 156 games with a line this season, the Astros have a mark of 77-79-0 against the spread.
• The Athletics have won 46.1% of the games this season they were the underdog on the moneyline (53-62).
• The Athletics have a record of 23-36 when they have played as a moneyline underdog with odds of +124 or longer (39%).
• The Athletics have played in 156 games with an over/under set, and have combined with their opponents to go over the total 75 times (75-74-7).
• The Athletics have put together an 83-73-0 record ATS this season (covering 53.2% of the time).

Astros Player Leaders

• Jose Altuve has an OPS of .766, fueled by an OBP of .325 and a team-best slugging percentage of .441 this season. He has a .263 batting average.
• Among all qualified batters in MLB, his batting average ranks 53rd, his on-base percentage ranks 79th, and he is 64th in slugging.
• Jeremy Pena leads Houston with 150 hits and an OBP of .363 this season. He's batting .304 and slugging .477.
• He ranks fifth in batting average, 16th in on-base percentage and 32nd in slugging among qualifying hitters.
• Yainer Diaz has collected 134 base hits, an OBP of .284 and a slugging percentage of .412 this season.
• Carlos Correa is batting .272 with a .328 OBP and 50 RBI for Houston this season.

Athletics Player Leaders

• Brent Rooker has a .485 slugging percentage, which leads the Athletics. He's batting .264 with an on-base percentage of .335.
• Including all the qualifying hitters in the majors, his batting average ranks 51st, his on-base percentage is 61st, and he is 24th in slugging.
• Tyler Soderstrom is hitting .278 with 32 doubles, a triple, 24 home runs and 53 walks. He's slugging .473 with an on-base percentage of .348.
• He ranks 26th in batting average, 43rd in on-base percentage and 38th in slugging percentage in MLB.
• Jacob Wilson has put up an on-base percentage of .362, a team-best for the Athletics.
• Nick Kurtz is hitting .291 with 26 doubles, two triples, 33 home runs and 60 walks.

Astros vs Athletics Head to Head

• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2025: 5-1 OAK (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2025: 15-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/24/2025: 5-2 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/19/2025: 6-4 OAK (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/18/2025: 11-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/17/2025: 13-3 HOU (Favorite: Astros, Spread: -1.5, Total: 11, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/16/2025: 3-1 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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