Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 4:15 a.m.

The Tuesday schedule in MLB includes a matchup between the New York Yankees and the San Diego Padres.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Padres Game Info

• New York Yankees (19-16) vs. San Diego Padres (23-11)
• Date: Tuesday, May 6, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: TBS, YES, and SDPA

Yankees vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-110) | SD: (-106)
• Spread: NYY: +1.5 (-176) | SD: -1.5 (+146)
• Total: 8 -- Over: (-110) | Under: (-110)

Yankees vs Padres Probable Starting Pitchers

Probable Pitchers: Clarke Schmidt (Yankees) - 0-1, 5.52 ERA vs Michael King (Padres) - 4-1, 2.09 ERA

The probable starters are Clarke Schmidt (0-1) for the Yankees and Michael King (4-1) for the Padres. Schmidt has a record of 0-2-0 ATS in two starts with a spread this season. Schmidt's team is 1-1 this season when he starts and they're favored on the moneyline. The Padres have a 4-3-0 ATS record in King's seven starts that had a set spread. The Padres were named the moneyline underdog for one King start this season -- they won.

Yankees vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (50.5%)

Yankees vs Padres Moneyline

• Looking at the moneyline for Yankees-Padres, New York is the favorite at -110, and San Diego is -106 playing on the road.

Yankees vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Yankees. The Padres are +146 to cover, while the Yankees are -176 to cover as a 1.5-run underdog on the runline.

Yankees vs Padres Over/Under

• The over/under for Yankees-Padres on May 6 is 8. The over is -110, and the under is -110.

Bet on New York Yankees vs. San Diego Padres on FanDuel today!

Yankees vs Padres Betting Trends

• The Yankees have been victorious in 17, or 60.7%, of the 28 contests they have been chosen as favorites in this season.
• New York has a record of 17-11 in contests when sportsbooks favor them by -110 or more on the moneyline.
• The Yankees and their opponents have gone over the total this season in 15 of their 34 opportunities.
• The Yankees are 16-18-0 against the spread in their 34 games that had a posted line this season.
• The Padres have put together an 8-7 record in games they were listed as the moneyline underdog (winning 53.3% of those games).
• When playing as a moneyline underdog with odds of -106 or longer, San Diego has a record of 8-7 (53.3%).
• In the 33 games oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total 13 times (13-19-1).
• The Padres have covered 60.6% of their games this season, going 20-13-0 against the spread.

Yankees Player Leaders

• Aaron Judge leads New York with 55 hits and an OBP of .503, plus a team-best slugging percentage of .759. He's batting .414.
• Among all qualified hitters, he ranks first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Paul Goldschmidt has eight doubles, three home runs and 10 walks. He's batting .353 and slugging .481 with an on-base percentage of .400.
• He ranks second in batting average, eighth in on-base percentage and 37th in slugging among qualifying hitters.
• Goldschmidt enters this game looking to extend his two-game hit streak. In his last five games he is batting .300 with two home runs, a walk and five RBI.
• Ben Rice is batting .255 with a .557 slugging percentage and 13 RBI this year.
• Trent Grisham has been key for New York with 25 hits, an OBP of .379 plus a slugging percentage of .631.
• Grisham brings a three-game hitting streak into this game. During his last five outings he is batting .313 with a home run, three walks and two RBI.

Padres Player Leaders

• Fernando Tatis Jr. has put up an on-base percentage of .387, a slugging percentage of .556, and has 40 hits, all club-bests for the Padres (while batting .317).
• Including all qualifying players, he ranks eighth in batting average, while his on-base percentage is 20th and he is 13th in slugging.
• Manny Machado is hitting .294 with 12 doubles, three home runs and 13 walks. He's slugging .460 with an on-base percentage of .357.
• Including all qualifying players, he is 25th in batting average, 47th in on-base percentage and 50th in slugging percentage.
• Luis Arraez is batting .297 with four doubles, a triple, three home runs and six walks.
• Xander Bogaerts is batting .254 with nine doubles, a home run and 16 walks.

Yankees vs Padres Head to Head

• 5/5/2025: 4-3 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2024: 5-2 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/25/2024: 4-1 NYY (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/24/2024: 8-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/28/2023: 10-7 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/26/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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