Cubs vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 6:11 a.m.

The Chicago Cubs will face the San Francisco Giants in MLB action on Tuesday.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Giants Game Info

• Chicago Cubs (22-14) vs. San Francisco Giants (22-14)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and NBCS-BA

Cubs vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-148) | SF: (+126)
• Spread: CHC: -1.5 (+138) | SF: +1.5 (-166)
• Total: 8 -- Over: (-110) | Under: (-110)

Cubs vs Giants Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 2-0, 1.46 ERA vs Justin Verlander (Giants) - 0-2, 4.62 ERA

This contest's pitching matchup is set, as the Cubs will send Colin Rea (2-0) to the mound, while Justin Verlander (0-2) will take the ball for the Giants. Rea and his team have covered in each of the three games he's started with a spread this season. This will be Rea's first game as the moneyline favorite this season. When Verlander starts, the Giants are 1-6-0 against the spread. The Giants were the underdog on the moneyline for three Verlander starts this season -- they lost each time.

Cubs vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.7%)

Cubs vs Giants Moneyline

• Chicago is a -148 favorite on the moneyline, while San Francisco is a +126 underdog on the road.

Cubs vs Giants Spread

• The Cubs are 1.5-run home favorites on the runline against the Giants. The Cubs are +138 to cover, and the Giants are -166.

Cubs vs Giants Over/Under

• A total of 8 runs has been set for the Cubs-Giants game on May 6, with the over available at -110 and the under at -110.

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Cubs vs Giants Betting Trends

• The Cubs have come away with 13 wins in the 17 contests they have been listed as the favorites in this season.
• This year Chicago has won five of seven games when listed as at least -148 on the moneyline.
• The Cubs and their opponents have hit the over in 22 of their 34 games with a total set by oddsmakers this season.
• The Cubs have an against the spread record of 19-15-0 in 34 games with a line this season.
• The Giants have won 46.2% of the games this season they were the underdog on the moneyline (6-7).
• San Francisco is 1-3 (winning just 25% of its games) when it has played as a moneyline underdog of +126 or longer.
• The Giants have played in 36 games with an over/under set, and have combined with opponents to go over the total 21 times (21-14-1).
• The Giants have a 17-19-0 record ATS this season (covering 47.2% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago with 40 hits and an OBP of .393 this season. He has a .284 batting average and a slugging percentage of .560.
• Among all qualified hitters, he is 36th in batting average, his on-base percentage ranks 15th, and he is 10th in slugging.
• Pete Crow-Armstrong is hitting .271 with 10 doubles, a triple, nine home runs and six walks, while slugging .550 with an on-base percentage of .306.
• Among all qualifying hitters, he ranks 52nd in batting average, 102nd in on-base percentage and 16th in slugging percentage.
• Crow-Armstrong heads into this game looking to extend his four-game hit streak. In his last five games he is batting .250 with three home runs and five RBI.
• Ian Happ has an OPS of .777, fueled by an OBP of .370 and a team-best slugging percentage of .407 this season.
• Happ has picked up a hit in seven games in a row. During his last 10 games he is batting .342 with four doubles, a home run, six walks and six RBI.
• Carson Kelly has been key for Chicago with 22 hits, an OBP of .500 plus a slugging percentage of .820.
• Kelly brings a six-game hitting streak into this matchup. In his last 10 outings he is hitting .324 with a double, four home runs, six walks and 10 RBI.

Giants Player Leaders

• Jung Hoo Lee has put up a team-high .485 slugging percentage. He's batting .303 with an on-base percentage of .359.
• Including all qualified players in MLB, his batting average puts him 17th, his on-base percentage is 42nd, and he is 35th in slugging.
• Matt Chapman is batting .210 with four doubles, seven home runs and 27 walks. He's slugging .411 with an on-base percentage of .351.
• He is currently 132nd in batting average, 53rd in on-base percentage and 79th in slugging percentage among all qualifying hitters.
• Michael Yastrzemski has put up an on-base percentage of .387 and has 30 hits, both team-best marks for the Giants.
• Wilmer Flores is batting .240 with two doubles, seven home runs and seven walks.

Cubs vs Giants Head to Head

• 5/5/2025: 9-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/27/2024: 5-3 CHC (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/26/2024: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/25/2024: 5-1 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/24/2024: 5-4 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/19/2024: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/18/2024: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/17/2024: 7-6 SF (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/6/2023: 8-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/5/2023: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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