White Sox vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 2:12 a.m.

In MLB action on Tuesday, the Chicago White Sox face the Pittsburgh Pirates.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Pirates Game Info

• Chicago White Sox (75-68) vs. Pittsburgh Pirates (71-73)
• Date: Tuesday, September 8, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SportsNet PT

White Sox vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-144) | PIT: (+122)
• Spread: CHW: -1.5 (+132) | PIT: +1.5 (-160)
• Total: 8.5 -- Over: (-106) | Under: (-114)

White Sox vs Pirates Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 8-6, 3.20 ERA vs Bubba Chandler (Pirates) - 6-9, 4.30 ERA

The White Sox will look to Sean Burke (8-6) against the Pirates and Bubba Chandler (6-9). Burke's team is 13-11-0 against the spread this season in his starts. Burke's team has been victorious in 77.8% of the games he's started as the moneyline favorite with a record of 7-2. The Pirates are 14-12-0 ATS in Chandler's 26 starts that had a set spread. The Pirates have a 6-10 record in Chandler's 16 starts this season when they were the moneyline underdog.

White Sox vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (50.8%)

White Sox vs Pirates Moneyline

• Pittsburgh is a +122 underdog on the moneyline, while Chicago is a -144 favorite at home.

White Sox vs Pirates Spread

• The Pirates are at the White Sox, and are +1.5 on the runline. The Pirates are +132 to cover the spread, and the White Sox are -160.

White Sox vs Pirates Over/Under

• White Sox versus Pirates on Sept. 8 has an over/under of 8.5 runs, with the odds on the over -106 and the under set at -114.

Bet on Chicago White Sox vs. Pittsburgh Pirates on FanDuel today!

White Sox vs Pirates Betting Trends

• The White Sox have won in 19, or 59.4%, of the 32 contests they have been named as odds-on favorites in this year.
• This season Chicago has come away with a win four times in six chances when named as a favorite of at least -144 on the moneyline.
• The White Sox and their opponents have hit the over in 77 of their 140 games with a total set by oddsmakers this season.
• The White Sox have posted a record of 81-59-0 against the spread this season.
• The Pirates have gone 27-37 in games they were the underdog on the moneyline (winning 42.2% of those games).
• Pittsburgh has a 7-14 record (winning only 33.3% of its games) when it has played as a moneyline underdog of +122 or longer.
• The Pirates have played in 142 games with a set over/under, and have combined with opponents to go over the total 74 times (74-64-4).
• The Pirates are 67-75-0 ATS this season.

White Sox Player Leaders

• Miguel Vargas leads Chicago in total hits (132) this season while batting .252 with 61 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .486.
• Among all qualified hitters in the majors, he ranks 74th in batting average, 25th in on-base percentage, and 22nd in slugging.
• Vargas hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .286 with a home run, a walk and three RBIs.
• Sam Antonacci has 113 hits this season and a team-best OBP of .367. He's batting .268 and slugging .393.
• Among qualified hitters, his batting average ranks him 46th, his on-base percentage 22nd, and his slugging percentage 99th.
• Tristan Peters is batting .285 with a .474 slugging percentage and 53 RBI this year.
• Peters takes a three-game hitting streak into this matchup. In his last five games he is hitting .471 with three doubles, a triple and an RBI.
• Chase Meidroth leads Chicago with a slugging percentage of .394, fueled by 39 extra-base hits.

Pirates Player Leaders

• Bryan Reynolds a has .373 on-base percentage to lead the Pirates. He's batting .266 while slugging .428.
• Including all qualifying hitters in the majors, he is 51st in batting average, 12th in on-base percentage and 62nd in slugging percentage.
• Brandon Lowe's 134 hits lead his team. He has a batting average of .256 while slugging .479 with an on-base percentage of .324.
• He is currently 68th in batting average, 80th in on-base percentage and 25th in slugging percentage among all qualified hitters.
• Nick Gonzales has a .393 slugging percentage, which paces the Pirates.
• Oneil Cruz is batting .265 with 11 doubles, a triple, 17 home runs and 41 walks.

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