Week 18 NFL Odds: Predictions, Spreads, Moneylines, and Totals for Every Game

The NFL's regular season comes to a close this week.

There are a lot of playoff implications, of course, and a lot of divisional rivalries to end the regular season.

Here are the NFL betting odds for each game in Week 18. All game predictions via numberFire.

Steelers at Ravens Week 18 Odds

• Pittsburgh Steelers Moneyline: -172
• Baltimore Ravens Moneyline: +144
• Spread: Steelers (-3)
• Total: 34.5
• numberFire Prediction: Ravens (56.9%)

Lamar Jackson is now a heavy MVP favorite (-9000 NFL MVP odds, per FanDuel Sportsbook) and an AP Offensive Player of the Year candidate (+6000) for the 1 seed in the AFC. Jackson will not play this week.

The Steelers' odds to make the NFL playoffs (+122) are quite reasonable, and they face a team with no motivation and are thus road favorites.

Pittsburgh won 17-10 in the first matchup between the two in one of the wilder comebacks of the season. George Pickens was a focal point there. He had 6 catches for 130 yards and 1 touchdown.

Texans at Colts Week 18 Odds

• Houston Texans Moneyline: -116
• Indianapolis Colts Moneyline: -102
• Spread: Texans (-1.5)
• Total: 47.5
• numberFire Prediction: Colts (51.9%)

The Texans got CJ Stroud back in Week 17, and Houston took advantage of it. They beat the Titans 26-3.

In Week 2's first meeting between the Texans and Colts, Stroud went for 384 yards and 2 touchdowns on 47 attempts in a 31-20 loss.

Gardner Minshew replaced Anthony Richardson in that game and posted a 112.1 passer rating.

This is a win-and-in matchup, and we've seen the line move to Houston's favor.

Falcons at Saints Week 18 Odds

• Atlanta Falcons Moneyline: +136
• New Orleans Saints Moneyline: -162
• Spread: Saints (-3)
• Total: 42.5
• numberFire Prediction: Saints (65.7%)

The first matchup in this series came in Week 12, which the Falcons won 24-15 at home despite getting out-earned 444 to 396. Some costly turnovers kept points down despite the yardage totals.

Both teams are alive in this matchup for the playoffs. The Falcons are +710, and the Saints are +250 to make the postseason.

The Saints would benefit greatly from a loss by the Buccaneers.

They list both RB Alvin Kamara and TE Juwan Johnson as questionable.

Browns at Bengals Week 18 Odds

• Cleveland Browns Moneyline: +265
• Cincinnati Bengals Moneyline: -330
• Spread: Bengals (-7.5)
• Total: 37.5
• numberFire Prediction: Bengals (68.5%)

Cleveland got off to a blazing start in Week 17's Thursday Night Football matchup against the Jets and clinched a playoff spot with their victory.

Joe Flacco remains red hot, and Cleveland is locked into the 5 seed. Flacco will sit out this week.

These two teams haven't played since Week 1. Naturally, a lot has changed since then -- particularly that the starting quarterbacks will be Flacco and Jake Browning.

But the Browns won that game 24-3 in Cleveland after out-gaining Cincinnati 350-142.

Jaguars at Titans Week 18 Odds

• Jacksonville Jaguars Moneyline: -198
• Tennessee Titans Moneyline: +166
• Spread: Jaguars (-3.5)
• Total: 41.5
• numberFire Prediction: Jaguars (55.6%)

The Titans have been a much different team at home (+4.3 point differential per game and a 4-4 record) than on the road (-9.6 point differential and a 1-6 record).

The Jaguars have been the complete opposite: -5.9 home point differential but a +3.6 on the road (a top-three rate in football).

Jacksonville's playoff odds remain high (-265), and a road win over the eliminated Titans this week would clinch the AFC South.

Trevor Lawrence (shoulder/finger) is questionable after limited practices all week.

Buccaneers at Panthers Week 18 Odds

• Tampa Bay Buccaneers Moneyline: -250
• Carolina Panthers Moneyline: +205
• Spread: Buccaneers (-4.5)
• Total: 36.5
• numberFire Prediction: Buccaneers (72.0%)

Carolina played the Bucs tough a few weeks back, but they couldn't complete a comeback and lost 21-18.

The Buccaneers need to win the NFC South in order to make the playoffs, meaning converting as road favorites over the Panthers, who were just shut out by the Jaguars.

Baker Mayfield (ribs) was upgraded to a full practice on Friday but is listed as questionable.

Jets at Patriots Week 18 Odds

• New York Jets Moneyline: +114
• New England Patriots Moneyline: -134
• Spread: Patriots (-1.5)
• Total: 30.5
• numberFire Prediction: Patriots (58.9%)

Both teams in this matchup are eliminated from playoff contention, and the Patriots are vying for a top pick in the 2024 NFL Draft.

In the first meeting between the two teams, New England beat the Jets 15-10 back in Week 3 and were out-gained 358 to 171.

Vikings at Lions Week 18 Odds

• Minnesota Vikings Moneyline: +154
• Detroit Lions Moneyline: -184
• Spread: Lions (-3)
• Total: 45.5
• numberFire Prediction: Lions (73.0%)

The Lions have been a great home team (+8.7 point differential and 5-2 overall), which bodes well for their Week 18 matchup against the Vikings, who were decimated by the Packers 33-10 on Sunday Night Football in Week 17.

The first matchup here took place recently: Week 16. Detroit won 30-24 while forcing 4 turnovers and controlling 38:22 of the clock.

Detroit still has a chance at the 2 seed, so they have motivation. Minnesota needs a win and a lot of help to make the playoffs.

Bears at Packers Week 18 Odds

• Chicago Bears Moneyline: +142
• Green Bay Packers Moneyline: -168
• Spread: Packers (-3)
• Total: 45
• numberFire Prediction: Packers (63.6%)

Green Bay heads back to Lambeau Field to close out the season. At Lambeau, they are 4-3 on the year with a surprisingly weak -1.9 point differential. They've averaged only 19.7 points per game at home, making them one of nine teams to average fewer than 20.0 at home.

Green Bay won 38-20 in Week 1 in Chicago with Jordan Love throwing for 245 yards and 3 touchdowns.

Justin Fields ran 9 times for 59 yards and completed 24 of 37 passes for 216 yards and a score.

Green Bay's odds to make the playoffs are -210.

Cowboys at Commanders Week 18 Odds

• Dallas Cowboys Moneyline: -950
• Washington Commanders Moneyline: +640
• Spread: Cowboys (-13.5)
• Total: 47.5
• numberFire Prediction: Cowboys (77.4%)

Washington has a chance to play spoiler for the Cowboys from a seeding standpoint, as Dallas can finish as the 2, 3, or 5 seed depending on how this week goes.

That being said, they couldn't keep the first matchup close and lost 45-10 on Thanksgiving Day.

Dak Prescott racked up 4 touchdowns and 331 yards in that matchup.

Seahawks at Cardinals Week 18 Odds

• Seattle Seahawks Moneyline: -146
• Arizona Cardinals Moneyline: +124
• Spread: Seahawks (-3)
• Total: 47.5
• numberFire Prediction: Seahawks (52.9%)

Seattle really needs another win over the Cardinals to sweep the season series.

They rode Kenneth Walker (105 yards on 26 carries) in the first meeting between the two, which Seattle won 20-10.

Seattle's odds to make the playoffs are +320, and their Week 17 loss means they don't control their own destiny.

Rams at 49ers Week 18 Odds

• Los Angeles Rams Moneyline: +180
• San Francisco 49ers Moneyline: -215
• Spread: 49ers (-4)
• Total: 41.5
• numberFire Prediction: 49ers (66.2%)

The 49ers were able to separate from the Rams in the second half in the first meeting between these two sides early in the year.

Christian McCaffrey ran 20 times for 116 yards and a touchdown.

Matthew Stafford went for 307 yards on a hefty 55 attempts, and Puka Nacua's early-year breakout was continuing. He had 20 targets for 15 catches and 147 yards.

San Francisco has locked up the 1 seed in the NFC. The Rams have clinched a playoff berth and will be either the 6 seed or the 7 seed.

Neither starting QB will play, and McCaffrey is also out.

Eagles at Giants Week 18 Odds

• Philadelphia Eagles Moneyline: -240
• New York Giants Moneyline: +198
• Spread: Eagles (-5.5)
• Total: 41.5
• numberFire Prediction: Eagles (69.6%)

The Giants nearly played spoiler in Week 16 for the Eagles but were unable to complete a Christmas Day comeback.

In that matchup, Tommy DeVito was replaced by Tyrod Taylor at halftime, and Taylor threw for 133 yards and a score, but Philadelphia held off the Giants 33-25. Taylor followed up with a big game in Week 17 in a near-comeback again.

In Week 16, Jalen Hurts compiled 301 yards as a passer and 34 on the ground. D'Andre Swift ran 20 times for 92 yards and a score in a positive game script.

The Eagles need a win, as they are hoping to claim the 2 seed and avoid the more likely 5 seed outcome.

WR DeVonta Smith is out.

Broncos at Raiders Week 18 Odds

• Denver Broncos Moneyline: +138
• Las Vegas Raiders Moneyline: -164
• Spread: Raiders (-3)
• Total: 37.5
• numberFire Prediction: Raiders (54.4%)

The Raiders and Broncos are eliminated from playoff contention.

Denver turned the offense over to QB Jarrett Stidham in Week 17 in lieu of Russell Wilson. In that matchup, Stidham threw for 224 yards and a touchdown in a 16-9 win over the Chargers.

Las Vegas beat Denver 17-16 back in Week 1.

Chiefs at Chargers Week 18 Odds

• Kansas City Chiefs Moneyline: +148
• Los Angeles Chargers Moneyline: -176
• Spread: Chargers (-3.5)
• Total: 35.5
• numberFire Prediction: Chargers (52.4%)

The first meeting in this series featured a lot of offense in the first half: the Chiefs led 24-17.

But the game ended 31-17 after things slowed down in the second half.

Patrick Mahomes racked up 424 yards and 4 touchdowns on his 42 attempts, and Travis Kelce went nuclear with 12 catches, 179 yards, and 1 touchdown.

Kansas City is locked into the 3 seed, and the Chargers are eliminated.

Mahomes won't play in Week 18.

Bills at Dolphins Week 18 Odds

• Buffalo Bills Moneyline: -152
• Miami Dolphins Moneyline: +128
• Spread: Bills (-2.5)
• Total: 48.5
• numberFire Prediction: Dolphins (53.7%)

The AFC East and the 2 seed is on the line this week to close out Week 18.

Miami will be looking to get their lick back on the Bills, who beat them 48-20 earlier this season in Buffalo.

Josh Allen threw for 320 yards and 4 touchdowns in that game. Stefon Diggs was on the receiving end of 120 yards and 3 touchdowns.

Miami's injury report is long. Raheem Mostert and Jaylen Waddle are both questionable.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.