Virginia vs Syracuse Prediction, Odds, Picks, Best Bets for Week 6 2026

NCAA football action on Saturday includes the Virginia Cavaliers playing the Syracuse Orange.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Virginia vs Syracuse Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Virginia: (-360) | Syracuse: (+280)
• Spread: Virginia: -8.5 (-118) | Syracuse: +8.5 (-104)
• Total: 50.5 -- Over: (-110) | Under: (-110)

Virginia vs Syracuse Betting Trends

• Virginia's record against the spread is 3-2-0.
• Virginia has two wins ATS (2-1) as an 8.5-point or higher favorite in 2026.
• Two of five Virginia games have gone over the point total this season.
• Syracuse has but one win versus the spread this year.
• Syracuse has no wins ATS (0-1) as an 8.5-point underdog or more this year.
• A pair of Syracuse four games in 2026 have gone over the point total.

Virginia vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (87%)

Virginia vs Syracuse Point Spread

Virginia is favored by 8.5 points over Syracuse. Virginia is -118 to cover the spread, with Syracuse being -104.

Virginia vs Syracuse Over/Under

Virginia versus Syracuse on Oct. 10 has an over/under of 50.5 points, with the over -110 and the under -110.

Virginia vs Syracuse Moneyline

Virginia is the favorite, -360 on the moneyline, while Syracuse is a +280 underdog.

Virginia vs. Syracuse Points Insights

Virginia vs. Syracuse Game Info

• Game day: Saturday, October 10, 2026
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Charlottesville, Virginia
• Stadium: Scott Stadium

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Check out even more in-depth Virginia vs. Syracuse analysis on FanDuel Research.