Virginia Tech vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 2 2025

Saturday's slate in college football includes a matchup between the Virginia Tech Hokies and the Vanderbilt Commodores.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Virginia Tech vs Vanderbilt Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Virginia Tech: (-128) | Vanderbilt: (+106)
• Spread: Virginia Tech: -2.5 (-105) | Vanderbilt: +2.5 (-115)
• Total: 47.5 -- Over: (-110) | Under: (-110)

Virginia Tech vs Vanderbilt Betting Trends

• Virginia Tech hasn't won a game against the spread this season.
• Vanderbilt has posted one win against the spread this season.
• Not one of Vanderbilt's one games has gone over the point total in 2025.

Virginia Tech vs Vanderbilt Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hokies win (59.7%)

Virginia Tech vs Vanderbilt Point Spread

Vanderbilt is an underdog by 2.5 points against Virginia Tech. Vanderbilt is -115 to cover the spread, and Virginia Tech is -105.

Virginia Tech vs Vanderbilt Over/Under

A total of 47.5 points has been set for the Virginia Tech-Vanderbilt game on Sept. 6, with the over available at -110 and the under at -110.

Virginia Tech vs Vanderbilt Moneyline

Vanderbilt is the underdog, +106 on the moneyline, while Virginia Tech is a -128 favorite.

Virginia Tech vs. Vanderbilt Points Insights

• The average implied total for the Hokies last season was 30.1 points, 5.1 more points than their implied total of 25 points in Saturday's game.
• The average implied point total last season for the Commodores (32.1) is 9.1 more points than the team's implied total in this matchup (23).

Virginia Tech vs. Vanderbilt Game Info

• Game day: Saturday, September 6, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Blacksburg, Virginia
• Stadium: Lane Stadium

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