USC vs Fresno State Prediction, Odds, Picks, Best Bets for Week 1 2026

The USC Trojans are among the college football teams in action on Friday, up against the Fresno State Bulldogs.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

USC vs Fresno State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-3030) | Fresno State: (+1200)
• Spread: USC: -21.5 (-110) | Fresno State: +21.5 (-110)
• Total: 51.5 -- Over: (-110) | Under: (-110)

USC vs Fresno State Betting Trends

• USC was 5-8-0 against the spread last season.
• USC had two wins ATS (2-1) as 21.5-point or greater favorites last year.
• In 13 USC games last season, seven hit the over.
• Fresno State had seven wins in 13 games against the spread last season.
• There were five Fresno State games (out of 13) that went over the total last year.

USC vs Fresno State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (93.3%)

USC vs Fresno State Point Spread

USC is a 21.5-point favorite against Fresno State. USC is -110 to cover the spread, and Fresno State is -110.

USC vs Fresno State Over/Under

The over/under for USC-Fresno State on Sept. 4 is 51.5. The over is -110, and the under is -110.

USC vs Fresno State Moneyline

The moneyline numbers for USC vs. Fresno State reveal USC as the favorite (-3030) and Fresno State as the underdog (+1200).

USC vs. Fresno State Points Insights

• The Trojans' average implied point total last season was 0.8 fewer points than their implied total in Friday's game (36.2 implied points on average compared to 37 implied points in this game).
• The average implied point total last season for the Bulldogs (27.9) is 12.9 more points than the team's implied total in this matchup (15).

USC vs. Fresno State Game Info

• Game day: Friday, September 4, 2026
• Game time: 9 p.m. ET
• TV channel: FOX
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Fresno State analysis on FanDuel Research.