Twins vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 5:15 a.m.

The MLB's Tuesday slate includes the Minnesota Twins facing the Baltimore Orioles.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs Orioles Game Info

• Minnesota Twins (15-20) vs. Baltimore Orioles (13-20)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and MASN

Twins vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-162) | BAL: (+136)
• Spread: MIN: -1.5 (+126) | BAL: +1.5 (-152)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Twins vs Orioles Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 2-2, 2.25 ERA vs Cade Povich (Orioles) - 1-2, 5.16 ERA

The probable pitchers are Pablo Lopez (2-2) for the Twins and Cade Povich (1-2) for the Orioles. Lopez's team is 3-2-0 against the spread this season in his starts. When Lopez starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Orioles have gone 1-5-0 ATS in Povich's six starts that had a set spread. The Orioles were the moneyline underdog for two Povich starts this season -- they split the games.

Twins vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (56.8%)

Twins vs Orioles Moneyline

• The moneyline numbers for Twins vs. Orioles reveal Minnesota as the favorite (-162) and Baltimore as the underdog (+136) on the road.

Twins vs Orioles Spread

• The Orioles are +1.5 on the run line against the Twins. The Orioles are -152 to cover, and the Twins are +126.

Twins vs Orioles Over/Under

• Twins versus Orioles on May 6 has an over/under of 8.5 runs, with the odds on the over -100 and the under set at -122.

Bet on Minnesota Twins vs. Baltimore Orioles on FanDuel today!

Twins vs Orioles Betting Trends

• The Twins have been victorious in 11, or 47.8%, of the 23 contests they have been chosen as favorites in this season.
• Minnesota has a record of 6-2 in contests when oddsmakers favor them by -162 or more on the moneyline.
• The Twins and their opponents have gone over the total this season in 12 of their 34 opportunities.
• The Twins have an against the spread record of 16-18-0 in 34 games with a line this season.
• The Orioles have won 42.9% of the games this season they were the underdog on the moneyline (6-8).
• Baltimore has played as a moneyline underdog of +136 or longer in only two games this season, which it lost both.
• The Orioles have had an over/under set by oddsmakers 33 times, and have combined with opponents to go over the total in 16 of those games (16-15-2).
• The Orioles have an 11-22-0 record against the spread this season.

Twins Player Leaders

• Byron Buxton has 33 hits to go with a slugging percentage of .488, both of which lead Minnesota hitters this season. He has a .260 batting average and an on-base percentage of .294.
• Among all qualified hitters, he ranks 64th in batting average, his on-base percentage ranks 118th, and he is 34th in slugging.
• Buxton has hit safely in five straight games. In his last five games he is hitting .364 with a home run, a walk and an RBI.
• Ty France leads Minnesota in OBP (.326) this season, fueled by 32 hits. He's batting .254 while slugging .381.
• Among qualified batters, he ranks 75th in batting average, 74th in on-base percentage and 104th in slugging percentage.
• Trevor Larnach is batting .230 with a .344 slugging percentage and 16 RBI this year.
• Larnach takes a three-game hitting streak into this game. In his last five games he is batting .263 with three walks and two RBI.
• Ryan Jeffers is batting .278 with a .363 OBP and 13 RBI for Minnesota this season.
• Jeffers brings a three-game hitting streak into this matchup. In his last five games he is hitting .375 with a double, a home run, a walk and three RBI.

Orioles Player Leaders

• Cedric Mullins has accumulated an on-base percentage of .379, a slugging percentage of .491, and has 28 hits, all club-highs for the Orioles (while batting .255).
• Including all qualified hitters, he ranks 72nd in batting average, while his on-base percentage is 30th and he is 30th in slugging.
• Ryan O'Hearn has four doubles, seven home runs and nine walks while hitting .306. He's slugging .600 with an on-base percentage of .379.
• Adley Rutschman has four doubles, four home runs and 17 walks while batting .216.
• Jackson Holliday has a double, a triple, four home runs and seven walks while hitting .273.

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