Twins vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 19

Odds updated as of 1:13 p.m.

The Wednesday schedule in MLB includes a matchup between the Minnesota Twins and the Cleveland Guardians.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Guardians Game Info

• Minnesota Twins (26-21) vs. Cleveland Guardians (25-21)
• Date: Wednesday, May 21, 2025
• Time: 1:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CLEG

Twins vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-118) | CLE: (-100)
• Spread: MIN: +1.5 (-200) | CLE: -1.5 (+164)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Twins vs Guardians Probable Starting Pitchers

Probable Pitchers: Bailey Ober (Twins) - 4-1, 3.72 ERA vs Logan Allen (Guardians) - 2-2, 3.70 ERA

The Twins will call on Bailey Ober (4-1) against the Guardians and Logan Allen (2-2). Ober and his team have a record of 6-3-0 against the spread when he starts. Ober's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. When Allen starts, the Guardians have gone 3-5-0 against the spread. The Guardians are 2-3 in Allen's five starts this season that they were the underdog on the moneyline.

Twins vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (57%)

Twins vs Guardians Moneyline

• Looking at the moneyline for Twins-Guardians, Minnesota is the favorite at -118, and Cleveland is -100 playing on the road.

Twins vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Twins. The Guardians are +164 to cover, while the Twins are -200 to cover as a 1.5-run underdog on the runline.

Twins vs Guardians Over/Under

• A combined run total of 7.5 has been set for Twins-Guardians on May 21, with the over at -102 and the under at -120.

Bet on Minnesota Twins vs. Cleveland Guardians on FanDuel today!

Twins vs Guardians Betting Trends

• The Twins have come away with 17 wins in the 29 contests they have been listed as the favorites in this season.
• This year Minnesota has won 15 of 21 games when listed as at least -118 on the moneyline.
• The Twins' games have gone over the total in 16 of their 46 opportunities.
• The Twins have posted a record of 26-20-0 against the spread this season.
• The Guardians have a 12-14 record in games they were the underdog on the moneyline (winning 46.2% of those games).
• Cleveland is 7-11 (winning only 38.9% of its games) when playing as a moneyline underdog of -100 or longer.
• In the 45 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 22 times (22-21-2).
• The Guardians have put together a 20-25-0 record ATS this season.

Twins Player Leaders

• Trevor Larnach leads Minnesota with an OBP of .330, plus a team-best slugging percentage of .419. He's batting .250 on the season.
• He is 91st in batting average, 79th in on-base percentage, and 81st in slugging among qualifying hitters in the majors.
• Larnach hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .238 with a double, a triple, a home run, two walks and two RBIs.
• Ty France is hitting .253 with eight doubles, three home runs and 10 walks. He's slugging .355 with an on-base percentage of .317.
• He ranks 87th in batting average, 100th in on-base percentage and 134th in slugging in MLB.
• Harrison Bader has 33 hits this season and has a slash line of .280/.366/.432.
• Ryan Jeffers has been key for Minnesota with 34 hits, an OBP of .345 plus a slugging percentage of .409.
• Jeffers has hit safely in three straight games. In his last five games he is hitting .364 with a double, a home run, a walk and an RBI.

Guardians Player Leaders

• Jose Ramirez has totaled 48 hits, a team-best for the Guardians. He's batting .296 and slugging .519 with an on-base percentage of .359.
• Including all qualified players in the majors, his batting average puts him 23rd, his on-base percentage is 47th, and he is 21st in slugging.
• Ramirez heads into this game on a 12-game hitting streak. During his last 10 games he is batting .378 with two doubles, four home runs, four walks and seven RBIs.
• Steven Kwan leads his team with a .374 on-base percentage, and has a club-high .428 slugging percentage. He has a batting average of .311.
• He is currently eighth in batting average, 29th in on-base percentage and 73rd in slugging percentage among all qualified hitters.
• Kyle Manzardo is hitting .221 with four doubles, two triples, 10 home runs and 18 walks.
• Carlos Santana has three doubles, four home runs and 23 walks while batting .222.

Twins vs Guardians Head to Head

• 5/1/2025: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/17/2024: 4-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2024: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2024: 5-3 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 6-3 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/9/2024: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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