Twins vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 18

Odds updated as of 4:11 a.m.

In MLB action on Monday, the Minnesota Twins face the Houston Astros.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Astros Game Info

• Minnesota Twins (21-26) vs. Houston Astros (19-29)
• Date: Monday, May 18, 2026
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and SCHN

Twins vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-116) | HOU: (-102)
• Spread: MIN: +1.5 (-184) | HOU: -1.5 (+152)
• Total: 9.5 -- Over: (-110) | Under: (-110)

Twins vs Astros Probable Starting Pitchers

Probable Pitchers: Kendry Rojas (Twins) - 1-0, 2.45 ERA vs Tatsuya Imai (Astros) - 1-1, 9.24 ERA

This contest's pitching matchup is set, as the Twins will send Kendry Rojas (1-0) to the mound, while Tatsuya Imai (1-1) will answer the bell for the Astros. Rojas did not pitch as the moneyline favorite last season. The Astros have a 2-2-0 record against the spread in Imai's starts. The Astros were named the moneyline underdog for two Imai starts this season -- they lost both.

Twins vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.5%)

Twins vs Astros Moneyline

• The moneyline numbers for Twins vs. Astros reveal Minnesota as the favorite (-116) and Houston as the underdog (-102) on the road.

Twins vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Twins. The Astros are +152 to cover, while the Twins are -184 to cover as a 1.5-run underdog on the runline.

Twins vs Astros Over/Under

• The Twins-Astros game on May 18 has been given an over/under of 9.5 runs. The over is set at -110 and the under at -110.

Bet on Minnesota Twins vs. Houston Astros on FanDuel today!

Twins vs Astros Betting Trends

• The Twins have been favorites in 14 games this season and have come away with the win six times (42.9%) in those contests.
• This year Minnesota has won two of seven games when listed as at least -116 on the moneyline.
• Contests with the Twins have gone over the total set by oddsmakers in 29 of 46 chances this season.
• The Twins are 24-22-0 against the spread in their 46 games with a line set by sportsbooks this season.
• The Astros have gone 13-18 in games they were the underdog on the moneyline (winning 41.9% of those games).
• Houston has a 12-16 record (winning 42.9% of its games) when playing as a moneyline underdog of -102 or longer.
• In the 48 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 28 times (28-18-2).
• The Astros have covered only 39.6% of their games this season, going 19-29-0 against the spread.

Twins Player Leaders

• Byron Buxton leads Minnesota with 44 hits and a team-best slugging percentage of .580. He's batting .260 with an on-base percentage of .319.
• Among qualified hitters in MLB, his batting average ranks 72nd, his on-base percentage ranks 103rd, and he is ninth in slugging.
• Ryan Jeffers leads Minnesota in OBP (.410) this season, fueled by 35 hits. He's batting .294 while slugging .538.
• Among qualified hitters, his batting average ranks him 25th, his on-base percentage fourth, and his slugging percentage 18th.
• Jeffers has picked up a hit in two straight games. In his last five games he is hitting .267 with two home runs, five walks and three RBIs.
• Brooks Lee has 39 hits this season and has a slash line of .247/.300/.380.
• Luke Keaschall is batting .232 with a .316 OBP and 15 RBI for Minnesota this season.
• Keaschall enters this game on a three-game hitting streak. During his last five outings he is batting .278 with a triple and a walk.

Astros Player Leaders

• Yordan Alvarez has put up an on-base percentage of .423, a slugging percentage of .638, and has 55 hits, all club-bests for the Astros (while batting .316).
• Including all the qualified hitters in the majors, he ranks 10th in batting average, second in on-base percentage and third in slugging percentage.
• Christian Walker is batting .263 with 10 doubles, 11 home runs and 18 walks. He's slugging .515 with an on-base percentage of .342.
• He is currently 62nd in batting average, 71st in on-base percentage and 23rd in slugging percentage among all qualifying hitters.
• Isaac Paredes has seven doubles, four home runs and 15 walks while hitting .250.
• Cam Smith is hitting .196 with six doubles, four home runs and 19 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!