Tulane vs Duke: College Football Prediction, Picks, Odds & Best Bets Today Week 1

College Football Betting Picks in Summary

• Duke -7.5
• Under 50.5
• Duke Over 404.5 Total Yards

Tulane travels to Duke Saturday afternoon in a genuinely competitive matchup, with Duke carrying a modest but real edge in the underlying yardage numbers.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Tulane at Duke (Sat, 3:30 p.m. ET)

Duke -7.5 (-110)

Duke's own projected yardage output (404.5) sits 70 yards clear of Tulane's (334.5), a real, meaningful gap that lines up with the home favorite number here.

Under 50.5 (-106)

Both rushing attacks project closely to each other (145.5 for Duke, 140.5 for Tulane), and with neither team leaning on an explosive vertical passing game based on these lines, this shapes up as a more grind-it-out, possession-based afternoon than a shootout.

Duke Over 404.5 Total Yards (-114)

Duke's rushing attack alone is projected for 145.5 yards, meaning the passing game only needs to contribute another 259 or so to clear this number — a reasonable ask for the favorite even in a game trending toward the under overall.