Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 9:11 p.m.

The MLB schedule on Thursday includes the Detroit Tigers taking on the Cleveland Guardians.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Guardians Game Info

• Detroit Tigers (20-29) vs. Cleveland Guardians (28-22)
• Date: Thursday, May 21, 2026
• Time: 1:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and CleGuardians.TV

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-116) | CLE: (-102)
• Spread: DET: +1.5 (-220) | CLE: -1.5 (+180)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Casey Mize (Tigers) - 2-2, 2.43 ERA vs Joey Cantillo (Guardians) - 3-1, 3.40 ERA

The Tigers will call on Casey Mize (2-2) versus the Guardians and Joey Cantillo (3-1). Mize's team is 4-3-0 against the spread this season in his starts. Mize's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Guardians have an 8-2-0 record against the spread in Cantillo's starts. The Guardians have a 4-1 record in Cantillo's five starts this season when they were the underdog on the moneyline.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (57.9%)

Tigers vs Guardians Moneyline

• The Tigers vs Guardians moneyline has Detroit as a -116 favorite, while Cleveland is a -102 underdog on the road.

Tigers vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Tigers. The Guardians are +180 to cover, while the Tigers are -220 to cover as a 1.5-run underdog on the runline.

Tigers vs Guardians Over/Under

• A combined run total of 7.5 has been set for Tigers-Guardians on May 21, with the over at -105 and the under at -115.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have been chosen as favorites in 25 games this year and have walked away with the win 13 times (52%) in those games.
• Detroit has a record of 13-10 when favored by -116 or more this year.
• The Tigers and their opponents have gone over in 21 of their 48 games with a total set by sportsbooks this season.
• The Tigers have posted a record of 24-24-0 against the spread this season.
• The Guardians are 11-10 in games they were listed as the moneyline underdog (winning 52.4% of those games).
• Cleveland has gone 10-9 in games it has played as a moneyline underdog with odds of -102 or longer (52.6%).
• In the 47 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 25 times (25-22-0).
• The Guardians have covered 53.2% of their games this season, going 25-22-0 ATS.

Tigers Player Leaders

• Kevin McGonigle is hitting .288 with 12 doubles, two triples, two home runs and 28 walks. He has an on-base percentage of .391 while slugging .412.
• Among qualified hitters in MLB, his batting average ranks 29th, his on-base percentage ranks 16th, and he is 83rd in slugging.
• McGonigle will look for his fifth straight game with a hit in this matchup. In his last five games he is hitting .250 with two walks.
• Riley Greene leads Detroit in OBP (.433), slugging percentage (.491) and total hits (58) this season. He's batting .335.
• He is second in batting average, first in on-base percentage and 32nd in slugging among qualified hitters.
• Greene has picked up at least one hit in two games in a row. In his last five games he is hitting .375 with two doubles, two walks and two RBIs.
• Dillon Dingler has collected 37 base hits, an OBP of .314 and a slugging percentage of .452 this season.
• Matt Vierling has four home runs, 19 RBI and a batting average of .212 this season.
• Vierling enters this game on a two-game hitting streak. In his last five games he is batting .278 with two home runs, two walks and two RBIs.

Guardians Player Leaders

• Jose Ramirez is batting .236 with 10 doubles, eight home runs and 37 walks. He's slugging .423 with an on-base percentage of .367.
• Including all qualified players, he is 113th in batting average, while his on-base percentage is 34th and he is 70th in slugging.
• Chase DeLauter's .470 slugging percentage paces his team. He has a batting average of .268 with an on-base percentage of .354.
• Including all qualified hitters, he ranks 53rd in batting average, 54th in on-base percentage and 45th in slugging percentage.
• Brayan Rocchio has racked up a team-best OBP (.369) and slugging percentage (.404).
• Angel Martinez's 40 hits lead his team.

Tigers vs Guardians Head to Head

• 5/19/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 10/2/2025: 6-3 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/1/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/30/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/25/2025: 4-2 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/23/2025: 5-2 CLE (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)

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