Southern Illinois vs Illinois Prediction, College Football Picks, Odds 3 Best Bets & Props

College Football Betting Picks in Summary

• Illinois -35.5
• Over 55.5
• Ca'Lil Valentine Anytime Touchdown

Southern Illinois travels to Illinois Saturday afternoon in one of the widest lines on the entire college football board — a +6500 moneyline for the visitors, with no two-way price even posted, a real sign of just how one-sided the market considers this one.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Southern Illinois at Illinois (Sat, 2:00 p.m. ET)

Illinois -35.5 (-108)

Illinois's own projected yardage output (509.5) is more than double Southern Illinois's (235.5) — a genuine, decisive talent gap between a Power Four program and an FCS opponent.

Over 55.5 (-106)

Illinois's own projected yardage output is enough on its own to comfortably clear this entire total, regardless of how little Southern Illinois manages to produce on the other side.

Ca'Lil Valentine Anytime Touchdown (-330)

The shortest price on the entire touchdown board, narrowly ahead of Collin Dixon — a real sign Valentine is expected to see a heavy workload against an outmatched FCS defense.