Senators vs Sabres NHL Prediction, Odds, Picks, Best Bets for Oct. 15

NHL action on Wednesday includes the Ottawa Senators taking on the Buffalo Sabres.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Senators vs Sabres Game Info

• Ottawa Senators (1-2) vs. Buffalo Sabres (0-3)
• Date: Wednesday, October 15, 2025
• Time: 7 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Senators vs Sabres Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Senators vs Sabres Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (52.7%)

Senators vs Sabres Puck Line

• The Sabres are underdogs by 1.5 goals (-250 to cover). And Ottawa, the favorite, is +198.

Senators vs Sabres Over/Under

• The over/under for Senators-Sabres on Oct. 15 is 5.5. The over is -142, and the under is +116.

Senators vs Sabres Moneyline

• Looking at the moneyline for Sabres-Senators, Buffalo is the underdog at +102, and Ottawa is -122 playing on the road.

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