Miami (FL) vs Louisville Prediction, Odds, Picks, Best Bets for Week 8 2025

The Friday slate in college football includes a matchup between the Miami Hurricanes and the Louisville Cardinals.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

Miami (FL) vs Louisville Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Miami (FL): (-559) | Louisville: (+420)
• Spread: Miami (FL): -13.5 (-122) | Louisville: +13.5 (100)
• Total: 51.5 -- Over: (-115) | Under: (-105)

Miami (FL) vs Louisville Betting Trends

• Miami (FL) has four wins in five games against the spread this year.
• Miami (FL) owns one win ATS (1-1) as a 13.5-point favorite or greater this season.
• Two of five Miami (FL) games have hit the over this year.
• Louisville has one win against the spread this year.
• Louisville has played five games this year, and three of them have hit the over.

Miami (FL) vs Louisville Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hurricanes win (85.1%)

Miami (FL) vs Louisville Point Spread

Miami (FL) is favored by 13.5 points (-122 to cover) in this matchup. Louisville, the underdog, is +100.

Miami (FL) vs Louisville Over/Under

Miami (FL) versus Louisville on Oct. 17 has an over/under of 51.5 points, with the over -115 and the under -105.

Miami (FL) vs Louisville Moneyline

Louisville is a +420 underdog on the moneyline, while Miami (FL) is a -559 favorite.

Miami (FL) vs. Louisville Points Insights

Miami (FL) vs. Louisville Game Info

• Game day: Friday, October 17, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Miami Gardens, Florida
• Stadium: Hard Rock Stadium

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Check out even more in-depth Miami (FL) vs. Louisville analysis on FanDuel Research.