Royals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 5:15 a.m.

The Kansas City Royals are among the MLB squads in action on Tuesday, up against the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Royals vs White Sox Game Info

• Kansas City Royals (20-16) vs. Chicago White Sox (10-25)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: FDSKC and CHSN

Royals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-220) | CHW: (+184)
• Spread: KC: -1.5 (-105) | CHW: +1.5 (-114)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Royals vs White Sox Probable Starting Pitchers

Probable Pitchers: Seth Lugo (Royals) - 3-3, 3.07 ERA vs Sean Burke (White Sox) - 2-4, 4.91 ERA

This contest's pitching matchup is set, as the Royals will send Seth Lugo (3-3) to the mound, while Sean Burke (2-4) will get the nod for the White Sox. Lugo and his team are 4-3-0 ATS this season when he starts. Lugo's team won his only start as a favorite this season. The White Sox have a 4-2-0 ATS record in Burke's six starts with a set spread. The White Sox have been the underdog on the moneyline in six of Burke's starts this season, and they went 3-3 in those matchups.

Royals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (65.5%)

Royals vs White Sox Moneyline

• Kansas City is a -220 favorite on the moneyline, while Chicago is a +184 underdog on the road.

Royals vs White Sox Spread

• The White Sox are +1.5 on the run line against the Royals. The White Sox are -114 to cover, and the Royals are -105.

Royals vs White Sox Over/Under

• A total of 8.5 runs has been set for the Royals-White Sox game on May 6, with the over available at -105 and the under at -115.

Bet on Kansas City Royals vs. Chicago White Sox on FanDuel today!

Royals vs White Sox Betting Trends

• The Royals have been victorious in 10, or 71.4%, of the 14 contests they have been chosen as favorites in this season.
• Kansas City has been a -220 moneyline favorite on three occasions this season and won every time.
• Contests with the Royals have gone over the total set by sportsbooks in 12 of 36 chances this season.
• The Royals have an against the spread record of 19-17-0 in 36 games with a line this season.
• The White Sox have won 10 of the 35 games they were the moneyline underdog this season (28.6%).
• When playing as a moneyline underdog with odds of +184 or longer, Chicago has a 4-12 record (winning only 25% of its games).
• The White Sox have had an over/under set by oddsmakers 35 times, and have combined with opponents to go over the total in 17 of those games (17-16-2).
• The White Sox have collected an 18-17-0 record ATS this season.

Royals Player Leaders

• Bobby Witt Jr. leads Kansas City in slugging percentage (.504) and total hits (43) this season. He's batting .314 with an on-base percentage of .389.
• He ranks 13th in batting average, 19th in on-base percentage, and 24th in slugging among qualified batters in MLB.
• Witt has recorded at least one hit in two games in a row. During his last five outings he is batting .263 with two doubles, two home runs, three walks and six RBI.
• Maikel Garcia leads Kansas City with an OBP of .390 this season while batting .322 with 14 walks and 15 runs scored. He's slugging .496.
• He is seventh in batting average, 18th in on-base percentage and 27th in slugging among qualifying hitters.
• Garcia takes a three-game streak with at least one hit into this one. In his last five games he is hitting .556 with a double, two home runs, four walks and five RBI.
• Vinnie Pasquantino has 26 hits this season and has a slash line of .191/.245/.375.
• Jonathan India is batting .230 with a .336 OBP and six RBI for Kansas City this season.
• India takes a three-game hitting streak into this matchup. In his last five games he is batting .300 with a double, a home run, three walks and an RBI.

White Sox Player Leaders

• Luis Robert has 22 hits, a team-best for the White Sox. He's batting .188 and slugging .342 with an on-base percentage of .304.
• He ranks 150th in batting average, 104th in on-base percentage and 129th in slugging percentage among all qualifying hitters in the majors.
• Miguel Vargas has a .319 on-base percentage to pace his team. He has a batting average of .223 while slugging .322.
• Including all qualified players, he is 118th in batting average, 84th in on-base percentage and 139th in slugging percentage.
• Andrew Benintendi is batting .224 with five home runs and eight walks.
• Brooks Baldwin is batting .240 with five doubles, three home runs and five walks.

Royals vs White Sox Head to Head

• 5/5/2025: 3-0 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/31/2024: 10-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 7/30/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 7/29/2024: 8-5 KC (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/21/2024: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 7/20/2024: 6-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 7/19/2024: 7-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/17/2024: 2-1 CHW (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/17/2024: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/15/2024: 2-0 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

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