Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 2:12 a.m.

The Cincinnati Reds versus the Pittsburgh Pirates is on the MLB schedule for Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Reds vs Pirates Game Info

• Cincinnati Reds (80-77) vs. Pittsburgh Pirates (68-89)
• Date: Wednesday, September 24, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SportsNet PT

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-118) | PIT: (-100)
• Spread: CIN: +1.5 (-210) | PIT: -1.5 (+172)
• Total: 7 -- Over: (-106) | Under: (-114)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Hunter Greene (Reds) - 7-4, 2.74 ERA vs Paul Skenes (Pirates) - 10-10, 2.03 ERA

The probable pitchers are Hunter Greene (7-4) for the Reds and Paul Skenes (10-10) for the Pirates. Greene's team is 6-11-0 against the spread this season in his starts. When Greene starts a game and his team is the favorite on the moneyline, they have a record of 7-3. When Skenes starts, the Pirates have gone 15-16-0 against the spread. The Pirates have a 5-4 record in Skenes' nine starts this season when they were the moneyline underdog.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (51.1%)

Reds vs Pirates Moneyline

• Cincinnati is the favorite, -118 on the moneyline, while Pittsburgh is a -100 underdog on the road.

Reds vs Pirates Spread

• The Pirates are 1.5-run favorites against the spread for this matchup with the Reds. The Pirates are +172 to cover, while the Reds are -210 to cover as a 1.5-run underdog on the runline.

Reds vs Pirates Over/Under

• Reds versus Pirates on Sept. 24 has an over/under of 7 runs, with the odds on the over -106 and the under set at -114.

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Reds vs Pirates Betting Trends

• The Reds have been favorites in 64 games this season and have come away with the win 34 times (53.1%) in those contests.
• This season Cincinnati has been victorious 27 times in 53 chances when named as a favorite of at least -118 on the moneyline.
• The Reds' games have gone over the total in 58 of their 149 opportunities.
• The Reds are 77-72-0 against the spread in their 149 games with a line set by sportsbooks this season.
• The Pirates are 42-61 in games they were listed as the moneyline underdog (winning 40.8% of those games).
• Pittsburgh has a 36-54 record (winning 40% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Pirates have combined with opponents to go over the total 57 times this season for a 57-86-6 record against the over/under.
• The Pirates have put together an 81-68-0 record against the spread this season (covering 54.4% of the time).

Reds Player Leaders

• Elly De La Cruz has 162 hits to go with a slugging percentage of .444, both of which are best among Cincinnati hitters this season. He has a .266 batting average and an on-base percentage of .340.
• Among all qualifying hitters in MLB, his batting average ranks 46th, his on-base percentage ranks 53rd, and he is 62nd in slugging.
• De La Cruz will look for his fifth straight game with a hit in this contest. In his last five games he is batting .429 with a double, two home runs, four walks and three RBIs.
• TJ Friedl leads Cincinnati with an OBP of .361 this season while batting .258 with 77 walks and 79 runs scored. He's slugging .370.
• Among all qualifying players, he is 70th in batting average, 20th in on-base percentage and 131st in slugging percentage.
• Spencer Steer has collected 118 base hits, an OBP of .312 and a slugging percentage of .418 this season.
• Austin Hays has 15 home runs, 64 RBI and a batting average of .266 this season.

Pirates Player Leaders

• Bryan Reynolds has 138 hits with a .401 slugging percentage, both team-high stats for the Pirates. He's batting .243 and with an on-base percentage of .315.
• He ranks 105th in batting average, 100th in on-base percentage and 98th in slugging percentage among all qualified hitters in the majors.
• Oneil Cruz has 18 doubles, three triples, 20 home runs and 64 walks while hitting .203. He's slugging .384 with an on-base percentage of .302.
• Including all qualified players, he ranks 145th in batting average, 118th in on-base percentage and 119th in slugging percentage.
• Andrew McCutchen has put up an on-base percentage of .336, a team-best for the Pirates.
• Spencer Horwitz is hitting .257 with 23 doubles, nine home runs and 41 walks.

Reds vs Pirates Head to Head

• 9/23/2025: 4-2 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/10/2025: 14-8 CIN (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/9/2025: 2-1 CIN (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/8/2025: 3-2 PIT (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2025: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 3-1 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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