Reds vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 28

Odds updated as of 5:14 a.m.

The Cincinnati Reds versus the San Diego Padres is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Reds vs Padres Game Info

• Cincinnati Reds (43-39) vs. San Diego Padres (44-37)
• Date: Saturday, June 28, 2025
• Time: 4:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SDPA

Reds vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-152) | SD: (+128)
• Spread: CIN: -1.5 (+126) | SD: +1.5 (-152)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Reds vs Padres Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 7-1, 1.79 ERA vs Randy Vasquez (Padres) - 3-4, 3.60 ERA

The Reds will give the nod to Andrew Abbott (7-1, 1.79 ERA), who is eyeing win No. 8 on the season, and the Padres will turn to Randy Vasquez (3-4, 3.60 ERA). Abbott's team is 8-4-0 against the spread in his starts this season. Abbott's team has won 85.7% of his starts when they are favored on the moneyline (6-1). The Padres have gone 8-7-0 ATS in Vasquez's 15 starts that had a set spread. The Padres are 3-7 in Vasquez's 10 starts this season that they were the moneyline underdog.

Reds vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.1%)

Reds vs Padres Moneyline

• The moneyline numbers for Reds vs. Padres reveal Cincinnati as the favorite (-152) and San Diego as the underdog (+128) on the road.

Reds vs Padres Spread

• The Reds are hosting the Padres and are favored by 1.5 runs on the spread. The Reds are +126 to cover the runline, with the Padres being -152.

Reds vs Padres Over/Under

• Reds versus Padres on June 28 has an over/under of 9.5 runs, with the odds on the over -105 and the under set at -115.

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Reds vs Padres Betting Trends

• The Reds have come away with 16 wins in the 31 contests they have been listed as the favorites in this season.
• Cincinnati has a record of 5-3 in contests when sportsbooks favor them by -152 or more on the moneyline.
• The Reds and their opponents have hit the over in 34 of their 78 games with a total set by oddsmakers this season.
• The Reds have an against the spread mark of 42-36-0 in 78 games with a line this season.
• The Padres are 16-20 in games they were listed as the moneyline underdog (winning 44.4% of those games).
• San Diego has a 6-11 record (winning only 35.3% of its games) when playing as a moneyline underdog of +128 or longer.
• In the 80 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 33 times (33-44-3).
• The Padres have a 42-38-0 record against the spread this season (covering 52.5% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.511) and total hits (88) this season. He's batting .279 with an on-base percentage of .352.
• Among the qualified hitters in the majors, his batting average ranks 42nd, his on-base percentage ranks 49th, and he is 19th in slugging.
• De La Cruz will look for his eighth straight game with a hit in this matchup. During his last 10 games he is hitting .325 with a double, two triples, two home runs, two walks and six RBIs.
• TJ Friedl leads Cincinnati with an OBP of .371 this season while batting .284 with 39 walks and 48 runs scored. He's slugging .421.
• He ranks 30th in batting average, 22nd in on-base percentage and 83rd in slugging among qualified hitters.
• Spencer Steer has 69 hits this season and has a slash line of .250/.302/.402.
• Steer takes a six-game hitting streak into this game. In his last 10 outings he is hitting .410 with three doubles, a triple, four home runs and nine RBIs.
• Gavin Lux is batting .266 with a .353 OBP and 36 RBI for Cincinnati this season.
• Lux has hit safely in three games in a row. In his last five games he is batting .200 with a home run, a walk and five RBIs.

Padres Player Leaders

• Manny Machado has racked up an on-base percentage of .357, a slugging percentage of .487, and has 91 hits, all club-bests for the Padres (while batting .295).
• Including all the qualifying hitters in the majors, he is 19th in batting average, 40th in on-base percentage and 30th in slugging percentage.
• Fernando Tatis Jr. is hitting .258 with 11 doubles, a triple, 15 home runs and 38 walks. He's slugging .450 with an on-base percentage of .348.
• His batting average ranks 77th among all qualified players, his on-base percentage ranks 53rd, and he is 57th in slugging.
• Luis Arraez is hitting .284 with 16 doubles, four triples, three home runs and 13 walks.
• Gavin Sheets is batting .259 with 12 doubles, a triple, 12 home runs and 22 walks.

Reds vs Padres Head to Head

• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2024: 5-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/2/2023: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 11, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/1/2023: 12-5 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/30/2023: 7-5 CIN (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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