Astros vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 28

Odds updated as of 6:12 a.m.

On Saturday in MLB, the Houston Astros are playing the Chicago Cubs.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Cubs Game Info

• Houston Astros (49-33) vs. Chicago Cubs (48-34)
• Date: Saturday, June 28, 2025
• Time: 7:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: FOX

Astros vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-124) | CHC: (+106)
• Spread: HOU: -1.5 (+162) | CHC: +1.5 (-196)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Astros vs Cubs Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 1-2, 4.91 ERA vs Colin Rea (Cubs) - 4-3, 4.42 ERA

The Astros will look to Lance McCullers (1-2) versus the Cubs and Colin Rea (4-3). McCullers' team is 4-3-0 against the spread in his starts this season. McCullers' team has a record of 1-3 this season when he starts and they are the favorite on the moneyline. The Cubs have a 6-5-0 record against the spread in Rea's starts. The Cubs have a 3-1 record in Rea's four starts this season when they were the moneyline underdog.

Astros vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.5%)

Astros vs Cubs Moneyline

• The Astros vs Cubs moneyline has Houston as a -124 favorite, while Chicago is a +106 underdog on the road.

Astros vs Cubs Spread

• The Cubs are +1.5 on the run line against the Astros. The Cubs are -196 to cover, and the Astros are +162.

Astros vs Cubs Over/Under

• An over/under of 8.5 has been set for Astros-Cubs on June 28, with the over being -122 and the under -100.

Bet on Houston Astros vs. Chicago Cubs on FanDuel today!

Astros vs Cubs Betting Trends

• The Astros have come away with 34 wins in the 56 contests they have been listed as the favorites in this season.
• This year Houston has won 23 of 37 games when listed as at least -124 on the moneyline.
• Contests with the Astros have gone over the total set by oddsmakers in 32 of 81 chances this season.
• In 81 games with a line this season, the Astros have a mark of 42-39-0 against the spread.
• The Cubs have compiled a 9-16 record in games they were listed as the moneyline underdog (winning 36% of those games).
• When playing as a moneyline underdog with odds of +106 or longer, Chicago has a 5-10 record (winning just 33.3% of its games).
• The Cubs have played in 80 games with an over/under set, and have combined with opponents to go over the total 43 times (43-33-4).
• The Cubs have a 40-40-0 record against the spread this season (covering 50% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston in OBP (.378), slugging percentage (.489) and total hits (102) this season. He has a .322 batting average.
• Among qualifying hitters, he is fourth in batting average, his on-base percentage ranks 16th, and he is 29th in slugging.
• Isaac Paredes is hitting .253 with 10 doubles, a triple, 16 home runs and 42 walks. He's slugging .462 with an on-base percentage of .358.
• He ranks 90th in batting average, 36th in on-base percentage and 51st in slugging in the major leagues.
• Jose Altuve has collected 80 base hits, an OBP of .322 and a slugging percentage of .414 this season.
• Altuve takes a two-game hitting streak into this game. During his last five outings he is hitting .167 with three walks.
• Jake Meyers has three home runs, 20 RBI and a batting average of .307 this season.
• Meyers has hit safely in three straight games. During his last five outings he is hitting .294 with a walk and an RBI.

Cubs Player Leaders

• Kyle Tucker a has .391 on-base percentage to lead the Cubs. He's batting .283 while slugging .520.
• He is 34th in batting average, eighth in on-base percentage and 14th in slugging percentage among all qualified hitters in MLB.
• Pete Crow-Armstrong's 85 hits lead his team. He has a batting average of .268 while slugging .549 with an on-base percentage of .304.
• Including all qualifying hitters, his batting average places him 60th, his on-base percentage ranks 121st, and he is eighth in slugging.
• Seiya Suzuki is hitting .259 with 19 doubles, two triples, 21 home runs and 28 walks.
• Nico Hoerner is slugging .378 to pace his team.

Astros vs Cubs Head to Head

• 6/27/2025: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/25/2024: 3-1 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/24/2024: 4-3 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/23/2024: 7-2 CHC (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/17/2023: 7-6 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/16/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/15/2023: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!