Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 6:14 p.m.

On Wednesday in MLB, the Boston Red Sox are up against the Cleveland Guardians.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Guardians Game Info

• Boston Red Sox (78-62) vs. Cleveland Guardians (68-69)
• Date: Wednesday, September 3, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CLEG

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-154) | CLE: (+130)
• Spread: BOS: -1.5 (+128) | CLE: +1.5 (-154)
• Total: 9 -- Over: (-110) | Under: (-110)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Brennan Bernardino (Red Sox) - 4-2, 3.08 ERA vs Joey Cantillo (Guardians) - 0-0, 0.00 ERA

The Red Sox will give the nod to Brennan Bernardino (4-2, 3.08 ERA), who is eyeing win No. 5 on the season, and the Guardians will counter with Joey Cantillo. Bernardino has a record of 0-2-0 ATS in two starts with a spread this season. Bernardino's team is 1-1 this season when he starts and they're favored on the moneyline. Cantillo and his team were underdogs on the moneyline in every game he pitched a season ago.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (61.2%)

Red Sox vs Guardians Moneyline

• Looking at the moneyline for Guardians-Red Sox, Cleveland is the underdog at +130, and Boston is -154 playing at home.

Red Sox vs Guardians Spread

• The Red Sox are hosting the Guardians and are favored by 1.5 runs (+128 to cover) on the runline. Cleveland is -154 to cover.

Red Sox vs Guardians Over/Under

• A total of 9 runs has been set for the Red Sox-Guardians game on Sept. 3, with the over available at -110 and the under at -110.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have won in 52, or 59.8%, of the 87 contests they have been named as odds-on favorites in this year.
• Boston has a record of 19-11 when favored by -154 or more this year.
• The Red Sox and their opponents have gone over the total this season in 67 of their 139 opportunities.
• The Red Sox are 76-63-0 against the spread in their 139 games with a line set by sportsbooks this season.
• The Guardians have put together a 32-45 record in games they were the underdog on the moneyline (winning 41.6% of those games).
• When playing as a moneyline underdog with odds of +130 or longer, Cleveland has an 11-15 record (winning 42.3% of its games).
• The Guardians have played in 134 games with an over/under set, and have combined with their opponents to go over the total 61 times (61-68-5).
• The Guardians are 69-65-0 ATS this season.

Red Sox Player Leaders

• Jarren Duran has 139 hits and an OBP of .336 to go with a slugging percentage of .450. All three of those stats are best among Boston hitters this season. He has a .259 batting average, as well.
• Among qualifying hitters in the majors, his batting average ranks 81st, his on-base percentage ranks 63rd, and he is 65th in slugging.
• Trevor Story is hitting .261 with 24 doubles, 23 home runs and 30 walks. He's slugging .438 with an on-base percentage of .308.
• He is 74th in batting average, 118th in on-base percentage and 73rd in slugging among qualifying hitters.
• Story has picked up at least one hit in two straight games. During his last five outings he is hitting .350 with two doubles, a home run, two walks and four RBIs.
• Ceddanne Rafaela has 118 hits this season and has a slash line of .251/.294/.427.
• Alex Bregman has 16 home runs, 54 RBI and a batting average of .285 this season.
• Bregman heads into this game on a three-game hitting streak. In his last five games he is hitting .136 with a double and an RBI.

Guardians Player Leaders

• Jose Ramirez has racked up an on-base percentage of .354 and has 140 hits, both team-high numbers for the Guardians. He's batting .280 and slugging .494.
• Including all qualified hitters in the majors, he ranks 26th in batting average, 35th in on-base percentage and 25th in slugging percentage.
• Steven Kwan paces his team with a .378 slugging percentage. He has a batting average of .271 with an on-base percentage of .328.
• Including all qualifying hitters, his batting average places him 42nd, his on-base percentage ranks 81st, and he is 132nd in slugging.
• Kyle Manzardo is hitting .233 with 14 doubles, two triples, 24 home runs and 41 walks.
• Angel Martinez is hitting .225 with 21 doubles, a triple, 10 home runs and 16 walks.

Red Sox vs Guardians Head to Head

• 9/2/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/25/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/24/2024: 8-0 BOS (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/23/2024: 4-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 2-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)

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