Red Sox vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 12:14 p.m.

On Sunday in MLB, the Boston Red Sox are playing the St. Louis Cardinals.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Cardinals Game Info

• Boston Red Sox (4-4) vs. St. Louis Cardinals (4-3)
• Date: Sunday, April 6, 2025
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and FDSMW

Red Sox vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-118) | STL: (-100)
• Spread: BOS: +1.5 (-188) | STL: -1.5 (+155)
• Total: 9 -- Over: (-108) | Under: (-112)

Red Sox vs Cardinals Probable Starting Pitchers

Probable Pitchers: Sean Newcomb (Red Sox) - 0-1, 9.00 ERA vs Andre Pallante (Cardinals) - 1-0, 3.60 ERA

This contest's pitching matchup is set, as the Red Sox will send Sean Newcomb (0-1) to the mound, while Andre Pallante (1-0) will take the ball for the Cardinals. Newcomb and his team failed to cover the spread in his only opportunity this season as a starter. This will be Newcomb's first start this season with his team as the moneyline favorite. Pallante has started just one game with a set spread, which the Cardinals covered. The Cardinals were the underdog on the moneyline for one Pallante start this season -- they won.

Red Sox vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.7%)

Red Sox vs Cardinals Moneyline

• The Red Sox vs Cardinals moneyline has Boston as a -118 favorite, while St. Louis is a -100 underdog on the road.

Red Sox vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Red Sox. The Cardinals are +155 to cover, while the Red Sox are -188 to cover as a 1.5-run underdog on the runline.

Red Sox vs Cardinals Over/Under

• A total of 9 runs has been set for the Red Sox-Cardinals game on April 6, with the over available at -108 and the under at -112.

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Red Sox vs Cardinals Betting Trends

• The Red Sox have been favorites in four games this season and have come away with the win three times (75%) in those contests.
• Boston has not lost in three games when named as a moneyline favorite of -118 or better.
• The Red Sox and their opponents have hit the over in three of their eight games with a total set by oddsmakers this season.
• The Red Sox are 5-3-0 against the spread in their eight games with a line set by sportsbooks this season.
• The Cardinals have won 75% of the games this season they were the underdog on the moneyline (3-1).
• St. Louis has played as a moneyline underdog of -100 or longer in just one game this season, which it lost.
• The Cardinals have combined with opponents to go over the total six times this season for a 6-1-0 record against the over/under.
• The Cardinals have covered 57.1% of their games this season, going 4-3-0 ATS.

Red Sox Player Leaders

• Wilyer Abreu leads Boston in OBP (.621), slugging percentage (1.000) and total hits (11) this season. He has a .500 batting average.
• Among all qualifying hitters, he ranks first in batting average, his on-base percentage ranks first, and he is second in slugging.
• Abreu has hit safely in two games in a row. In his last five games he is batting .385 with a double, a home run, five walks and three RBI.
• Kristian Campbell has an OPS of 1.323, fueled by an OBP of .515 and a team-best slugging percentage of .808 this season. He's batting .423.
• Among qualified batters, he ranks third in batting average, third in on-base percentage and fifth in slugging percentage.
• Campbell heads into this matchup looking to extend his three-game hit streak. In his last five games he is batting .375 with three doubles, a home run, four walks and four RBI.
• Alex Bregman has an OPS of .837, fueled by an OBP of .351 and a team-best slugging percentage of .486 this season.
• Bregman enters this game with seven games in a row with at least one hit. In his last eight outings he is batting .314 with three doubles, a home run, two walks and four RBI.
• Trevor Story is batting .250 with a .276 OBP and four RBI for Boston this season.

Cardinals Player Leaders

• Ivan Herrera has racked up eight hits, a team-best for the Cardinals. He's batting .400 and slugging 1.100 with an on-base percentage of .455.
• Including all qualified hitters, he ranks seventh in batting average, while his on-base percentage is 13th and he is first in slugging.
• Lars Nootbaar has a .514 on-base percentage while slugging .655. Both are team-highs. He has a batting average of .414.
• Including all qualified hitters, he is fourth in batting average, fourth in on-base percentage and 16th in slugging percentage.
• Nolan Arenado has three doubles, a home run and five walks while batting .357.
• Victor Scott II has a double, a home run and three walks while hitting .308.

Red Sox vs Cardinals Head to Head

• 4/4/2025: 13-9 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/19/2024: 11-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/18/2024: 7-2 STL (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/17/2024: 10-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/14/2023: 9-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/13/2023: 4-3 STL (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/12/2023: 8-6 STL (Favorite: Red Sox, Spread: -1.5, Total: 11, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/19/2022: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/18/2022: 11-2 STL (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/17/2022: 6-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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