Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 4:21 p.m.

The Cleveland Guardians are among the MLB teams in action on Monday, up against the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Guardians vs Twins Game Info

• Cleveland Guardians (15-12) vs. Minnesota Twins (12-16)
• Date: Monday, April 28, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MNNT

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-132) | MIN: (+112)
• Spread: CLE: -1.5 (+158) | MIN: +1.5 (-192)
• Total: 8 -- Over: (-115) | Under: (-105)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 2-1, 4.15 ERA vs Bailey Ober (Twins) - 2-1, 5.04 ERA

The Guardians will give the nod to Gavin Williams (2-1) against the Twins and Bailey Ober (2-1). Williams and his team are 3-2-0 ATS this season when he starts. Williams' team is 2-0 this season when he starts and they're favored on the moneyline. When Ober starts, the Twins have gone 3-2-0 against the spread. The Twins were the underdog on the moneyline for one Ober start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (54.7%)

Guardians vs Twins Moneyline

• The Guardians vs Twins moneyline has Cleveland as a -132 favorite, while Minnesota is a +112 underdog on the road.

Guardians vs Twins Spread

• The Guardians are favored by 1.5 runs at home against the Twins. The Guardians are +158 to cover the spread, while the Twins are -192.

Guardians vs Twins Over/Under

• The over/under for the Guardians versus Twins contest on April 28 has been set at 8, with -115 odds on the over and -105 odds on the under.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been chosen as favorites in 10 games this year and have walked away with the win eight times (80%) in those games.
• This season Cleveland has been victorious four times in five chances when named as a favorite of at least -132 on the moneyline.
• The Guardians and their opponents have gone over in 15 of their 27 games with a total set by sportsbooks this season.
• The Guardians are 12-15-0 against the spread in their 27 games that had a posted line this season.
• The Twins have not yet won as the moneyline underdog this season, going 7-10.
• Minnesota has played as a moneyline underdog of +112 or longer in just two games this season, which it lost both.
• The Twins have played in 28 games with a set over/under, and have combined with opponents to go over the total 10 times (10-15-3).
• The Twins have covered 50% of their games this season, going 14-14-0 against the spread.

Guardians Player Leaders

• Steven Kwan has an OPS of .901, fueled by an OBP of .397 to go with a slugging percentage of .505. He has a .346 batting average, as well.
• He is fourth in batting average, 15th in on-base percentage, and 31st in slugging among all qualifying hitters in MLB.
• Kwan has recorded at least one hit in 10 games in a row. During his last 10 outings he is batting .400 with four doubles, a home run, three walks and four RBI.
• Jose Ramirez is hitting .263 with four doubles, five home runs and nine walks, while slugging .463 with an on-base percentage of .321.
• Among all qualifying hitters, he is 59th in batting average, 84th in on-base percentage and 47th in slugging percentage.
• Kyle Manzardo has 17 hits and is batting .210 this season.
• Gabriel Arias is batting .272 with a .318 OBP and 11 RBI for Cleveland this season.
• Arias takes a three-game hitting streak into this matchup. During his last five outings he is hitting .250 with two doubles and an RBI.

Twins Player Leaders

• Byron Keiron Buxton has racked up a team-high slugging percentage (.505) and leads the Twins in hits (23). He's batting .237 and with an on-base percentage of .269.
• Including all qualified hitters in the majors, he is 95th in batting average, 137th in on-base percentage and 31st in slugging percentage.
• Trevor Larnach has a .330 OBP to lead his team. He has a batting average of .234 while slugging .383.
• Including all qualifying hitters, his batting average puts him 100th, his on-base percentage is 72nd, and he is 96th in slugging.
• Ty France has a .351 slugging percentage, which leads the Twins.
• Carlos Javier Correa is hitting .211 with seven doubles, a home run and seven walks.

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