Rays vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 4:17 a.m.

Tuesday's slate in the MLB includes a matchup between the Tampa Bay Rays and the Toronto Blue Jays.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Rays vs Blue Jays Game Info

• Tampa Bay Rays (73-77) vs. Toronto Blue Jays (88-62)
• Date: Tuesday, September 16, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and SNET

Rays vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-112) | TOR: (-104)
• Spread: TB: +1.5 (-188) | TOR: -1.5 (+155)
• Total: 8 -- Over: (-118) | Under: (-104)

Rays vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Ryan Pepiot (Rays) - 11-10, 3.59 ERA vs José Berrios (Blue Jays) - 9-5, 3.99 ERA

The Rays will give the nod to Ryan Pepiot (11-10, 3.59 ERA), who is eyeing win No. 12 on the season, and the Blue Jays will counter with Jose Berrios (9-5, 3.99 ERA). Pepiot's team is 10-18-0 against the spread in his starts this season. Pepiot's team has a record of 9-5 this season when he starts and they are the favorite on the moneyline. When Berrios starts, the Blue Jays are 17-12-0 against the spread. The Blue Jays are 9-3 in Berrios' 12 starts this season that they were the moneyline underdog.

Rays vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (51.6%)

Rays vs Blue Jays Moneyline

• Toronto is a -104 underdog on the moneyline, while Tampa Bay is a -112 favorite at home.

Rays vs Blue Jays Spread

• The Blue Jays are 1.5-run favorites against the spread for this matchup with the Rays. The Blue Jays are +155 to cover, while the Rays are -188 to cover as a 1.5-run underdog on the runline.

Rays vs Blue Jays Over/Under

• Rays versus Blue Jays on Sept. 16 has an over/under of 8 runs, with the odds on the over -118 and the under set at -104.

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Rays vs Blue Jays Betting Trends

• The Rays have won in 39, or 56.5%, of the 69 contests they have been named as odds-on favorites in this year.
• This season Tampa Bay has been victorious 39 times in 69 chances when named as a favorite of at least -112 on the moneyline.
• Contests with the Rays have gone over the total set by oddsmakers in 63 of 145 chances this season.
• The Rays have an against the spread record of 63-82-0 in 145 games with a line this season.
• The Blue Jays are 41-32 in games they were listed as the moneyline underdog (winning 56.2% of those games).
• Toronto is 35-29 (winning 54.7% of its games) when playing as a moneyline underdog of -104 or longer.
• The Blue Jays have played in 149 games with an over/under set, and have combined with opponents to go over the total 81 times (81-62-6).
• The Blue Jays have covered 58.4% of their games this season, going 87-62-0 ATS.

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 148 hits, batting .260 this season with 72 extra-base hits. He has an on-base percentage of .301 and a slugging percentage of .541.
• Among qualifying batters in the majors, his batting average ranks 71st, his on-base percentage ranks 122nd, and he is eighth in slugging.
• Yandy Diaz is slashing .295/.356/.479 this season and leads the Rays with an OPS of .835.
• Among qualified hitters, his batting average ranks him ninth, his on-base percentage 28th, and his slugging percentage 31st.
• Diaz enters this matchup looking to extend his three-game hit streak. In his last five games he is batting .421 with a double, two home runs, five walks and three RBIs.
• Brandon Lowe has 122 hits this season and has a slash line of .256/.308/.471.
• Chandler Simpson is batting .291 with a .324 OBP and 23 RBI for Tampa Bay this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has a team-best .395 on-base percentage. He's batting .301 and slugging .490.
• Including all the qualified hitters in the majors, his batting average ranks sixth, his on-base percentage ranks third, and he is 24th in slugging.
• George Springer paces his team with 136 hits. He has a batting average of .302 while slugging .550 with an on-base percentage of .394.
• Including all qualifying players, he is fifth in batting average, fifth in on-base percentage and sixth in slugging percentage.
• Ernie Clement is batting .279 with 31 doubles, two triples, nine home runs and 24 walks.
• Alejandro Kirk is batting .291 with 17 doubles, 12 home runs and 45 walks.

Rays vs Blue Jays Head to Head

• 9/15/2025: 2-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 13-0 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/24/2025: 3-1 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/23/2025: 3-1 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/15/2025: 8-3 TB (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/14/2025: 3-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/13/2025: 11-9 TB (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/22/2024: 4-3 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/21/2024: 3-2 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/20/2024: 1-0 TB (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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