Pittsburgh vs Syracuse Prediction, Odds, Picks, Best Bets for Week 3 2026

College football's Thursday slate includes the Pittsburgh Panthers facing the Syracuse Orange.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Pittsburgh vs Syracuse Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Pittsburgh: (-375) | Syracuse: (+290)
• Spread: Pittsburgh: -10.5 (-102) | Syracuse: +10.5 (-120)
• Total: 51.5 -- Over: (-110) | Under: (-110)

Pittsburgh vs Syracuse Betting Trends

• Pittsburgh has posted one win against the spread this season.
• Pittsburgh has yet to lose ATS (1-0) as a 10.5-point favorite or greater this year.
• Pittsburgh has had one game (of two) hit the over this season.
• Syracuse has posted one win against the spread this year.
• One of Syracuse's two games has hit the over.

Pittsburgh vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Panthers win (91.4%)

Pittsburgh vs Syracuse Point Spread

Pittsburgh is favored by 10.5 points over Syracuse. Pittsburgh is -102 to cover the spread, with Syracuse being -120.

Pittsburgh vs Syracuse Over/Under

The over/under for the Pittsburgh versus Syracuse game on Sept. 17 has been set at 51.5, with -110 odds on the over and -110 odds on the under.

Pittsburgh vs Syracuse Moneyline

Pittsburgh is a -375 favorite on the moneyline, while Syracuse is a +290 underdog.

Pittsburgh vs. Syracuse Points Insights

Pittsburgh vs. Syracuse Game Info

• Game day: Thursday, September 17, 2026
• Game time: 7:30 p.m. ET
• TV channel: ESPN
• Location: Pittsburgh, Pennsylvania
• Stadium: Acrisure Stadium

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Check out even more in-depth Pittsburgh vs. Syracuse analysis on FanDuel Research.