Pistons vs. 76ers Prediction, Odds, Picks, Best Bets for Nov. 4

Pistons vs. 76ers Game Info

• Date: Wednesday, November 4, 2026
• Time: 7 p.m. ET
• Venue: Little Caesars Arena -- Detroit, Michigan
• Coverage: ESPN, NBCS-PH, and PCK-PHI

The Detroit Pistons (6-1) will look to extend a three-game win streak when they host the Philadelphia 76ers (7-1) at 7 p.m. ET on Wednesday, November 4, 2026 as 1.5-point favorites. The 76ers have won four games in a row. The matchup's point total is 219.5.

Pistons vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Pistons vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (77.8%)

Pistons vs. 76ers Betting Trends

• The Pistons are 6-1-0 against the spread this season.
• In the 76ers' eight games this year, they have five wins against the spread.
• This season, Pistons games have hit the over three times out of eight chances.
• 76ers games this season have gone over the total in two of eight opportunities (25%).

Pistons Leaders

• Cade Cunningham is averaging 23.7 points, 5.4 boards and 7.1 assists. Defensively, he averages 1.6 steals and 1.1 blocked shots.
• Paul Reed averages 13.4 points, 6.7 boards and 2.1 assists, shooting 65.0% from the floor (sixth in league).
• Duncan Robinson averages 17.9 points, 2.0 boards and 2.3 assists.
• Ausar Thompson's numbers on the season are 9.7 points, 7.2 boards and 5.0 assists per contest, shooting 55.8% from the field.
• Daniss Jenkins' numbers on the season are 9.9 points, 3.4 boards and 4.4 assists per game, shooting 44.4% from the field and 41.7% from downtown, with an average of 1.4 made treys.

76ers Leaders

• Tyrese Maxey averages 29.1 points, 4.1 boards and 5.3 assists. He is also draining 50.3% of his shots from the field and 33.9% from beyond the arc, with 2.5 triples per contest.
• Jaylen Brown's numbers on the season are 20.6 points, 6.9 rebounds and 4.3 assists per game. He is draining 45.7% of his shots from the field and 41.9% from 3-point range, with an average of 1.9 triples.
• The 76ers are receiving 16.2 points, 7.0 rebounds and 7.3 assists per game from LeBron James.
• Joel Embiid averages 18.5 points, 9.2 boards and 4.8 assists. He is draining 40.7% of his shots from the field.
• The 76ers receive 12.7 points per game from VJ Edgecombe, plus 7.1 boards and 3.0 assists.

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