Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for May 28

Odds updated as of 2:12 a.m.

In MLB action on Thursday, the Pittsburgh Pirates take on the Chicago Cubs.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (29-27) vs. Chicago Cubs (30-26)
• Date: Thursday, May 28, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-174) | CHC: (+146)
• Spread: PIT: -1.5 (+122) | CHC: +1.5 (-146)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 6-4, 3.00 ERA vs Colin Rea (Cubs) - 4-3, 4.83 ERA

The probable pitchers are Paul Skenes (6-4) for the Pirates and Colin Rea (4-3) for the Cubs. Skenes' team is 5-6-0 against the spread this season in his starts. When Skenes starts a game and his team is the favorite on the moneyline, they have a record of 6-4. The Cubs have a 2-6-0 record against the spread in Rea's starts. The Cubs have a 1-2 record in Rea's three starts this season when they were the moneyline underdog.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (57.2%)

Pirates vs Cubs Moneyline

• The moneyline numbers for Pirates vs. Cubs reveal Pittsburgh as the favorite (-174) and Chicago as the underdog (+146) on the road.

Pirates vs Cubs Spread

• The Cubs are +1.5 on the spread (-146 to cover), and Pittsburgh is +122 to cover the runline.

Pirates vs Cubs Over/Under

• The Pirates-Cubs contest on May 28 has been given an over/under of 7.5 runs. The over is set at -112 and the under at -108.

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Pirates vs Cubs Betting Trends

• The Pirates have come away with 19 wins in the 32 contests they have been listed as the favorites in this season.
• This year Pittsburgh has won four of seven games when listed as at least -174 on the moneyline.
• The Pirates and their opponents have gone over in 28 of their 55 games with a total set by sportsbooks this season.
• The Pirates have an against the spread mark of 28-27-0 in 55 games with a line this season.
• The Cubs have won 50% of the games this season they were the underdog on the moneyline (9-9).
• Chicago has played as a moneyline underdog of +146 or longer in just two games this season, which it split 1-1.
• The Cubs have combined with opponents to hit the over on the total 31 times this season for a 31-24-0 record against the over/under.
• The Cubs have a 22-33-0 record against the spread this season.

Pirates Player Leaders

• Brandon Lowe leads Pittsburgh with 52 hits, batting .269 this season with 27 extra-base hits. He has an on-base percentage of .355 and a slugging percentage of .560.
• Among all qualifying batters in MLB, he ranks 50th in batting average, 44th in on-base percentage, and seventh in slugging.
• Lowe will look for his fifth straight game with a hit in this contest. In his last five games he is batting .333 with a double, a home run and four RBIs.
• Bryan Reynolds is hitting .266 with 11 doubles, two triples, four home runs and 36 walks. He's slugging .402 with an on-base percentage of .385.
• His batting average is 56th among qualified players, his on-base percentage 19th, and his slugging percentage 86th.
• Reynolds has picked up at least one hit in five games in a row. In his last five games he is hitting .500 with three doubles, two walks and two RBIs.
• Oneil Cruz has hit 11 homers with a team-high .453 SLG this season.
• Spencer Horwitz has 45 hits this season and a team-best OBP of .388.
• Horwitz heads into this matchup on a five-game hitting streak. In his last five games he is batting .412 with two home runs, two walks and three RBIs.

Cubs Player Leaders

• Nico Hoerner has 13 doubles, four home runs and 26 walks while batting .256. He's slugging .370 with an on-base percentage of .341.
• Including all the qualified hitters in the big leagues, his batting average puts him 77th, his on-base percentage is 67th, and he is 116th in slugging.
• Michael Busch paces his team with a .366 OBP. He has a batting average of .232 while slugging .389.
• His batting average is 110th among all qualified players, his on-base percentage ranks 35th, and he is 98th in slugging.
• Ian Happ has collected 42 hits, a team-high for the Cubs.
• Dansby Swanson is batting .190 with five doubles, a triple, seven home runs and 26 walks.

Pirates vs Cubs Head to Head

• 5/27/2026: 10-4 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)

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