Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 6:11 a.m.

The Pittsburgh Pirates will face the St. Louis Cardinals in MLB action on Tuesday.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (12-24) vs. St. Louis Cardinals (17-19)
• Date: Tuesday, May 6, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SportsNet PT

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-126) | STL: (+108)
• Spread: PIT: -1.5 (+134) | STL: +1.5 (-162)
• Total: 7 -- Over: (-118) | Under: (-104)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-3, 2.74 ERA vs Matthew Liberatore (Cardinals) - 2-3, 3.44 ERA

This contest's pitching matchup is set, as the Pirates will send Paul Skenes (3-3) to the mound, while Matthew Liberatore (2-3) will take the ball for the Cardinals. Skenes' team is 3-4-0 against the spread this season in his starts. Skenes' team has won 33.3% of his starts when they are favored on the moneyline (2-4). The Cardinals have a 1-5-0 record against the spread in Liberatore's starts. The Cardinals were the moneyline underdog for two Liberatore starts this season -- they split the games.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (58.1%)

Pirates vs Cardinals Moneyline

• St. Louis is the underdog, +108 on the moneyline, while Pittsburgh is a -126 favorite despite being on the road.

Pirates vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Pirates. The Cardinals are -162 to cover the spread, and the Pirates are +134.

Pirates vs Cardinals Over/Under

• The Pirates-Cardinals game on May 6 has been given an over/under of 7 runs. The over is set at -118 and the under at -104.

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Pirates vs Cardinals Betting Trends

• The Pirates have won in five, or 41.7%, of the 12 contests they have been named as odds-on favorites in this year.
• This season Pittsburgh has been victorious three times in seven chances when named as a favorite of at least -126 on the moneyline.
• The Pirates' games have gone over the total in 17 of their 35 opportunities.
• The Pirates are 12-23-0 against the spread in their 35 games with a line set by sportsbooks this season.
• The Cardinals have gone 12-13 in games they were the underdog on the moneyline (winning 48% of those games).
• St. Louis has a record of 5-8 in games it has played as a moneyline underdog with odds of +108 or longer (38.5%).
• The Cardinals have had an over/under set by oddsmakers 36 times, and have combined with opponents to go over the total in 21 of those games (21-13-2).
• The Cardinals have covered 47.2% of their games this season, going 17-19-0 against the spread.

Pirates Player Leaders

• Oneil Cruz leads Pittsburgh in OBP (.385) and total hits (29) this season. He's batting .252 batting average while slugging .504.
• Among qualifying batters in the majors, he is 80th in batting average, 22nd in on-base percentage, and 24th in slugging.
• Bryan Reynolds has hit five homers this season while driving in 19 runs. He's batting .231 this season and slugging .371 with an on-base percentage of .296.
• Among all qualifying players, he is 106th in batting average, 115th in on-base percentage and 113th in slugging percentage.
• Andrew McCutchen has collected 25 base hits, an OBP of .345 and a slugging percentage of .404 this season.
• Enmanuel Valdez is batting .221 with a .309 OBP and 12 RBI for Pittsburgh this season.

Cardinals Player Leaders

• Lars Nootbaar has seven doubles, five home runs and 27 walks while batting .237. He's slugging .400 with an on-base percentage of .368.
• He is 99th in batting average, 37th in on-base percentage and 87th in slugging percentage among all qualifying batters in the big leagues.
• Brendan Donovan has 44 hits with a .393 on-base percentage while slugging .481. Those stats all lead his team. He also has a batting average of .336.
• His batting average is fifth among all qualified players, his on-base percentage ranks 15th, and he is 37th in slugging.
• Nolan Arenado is hitting .256 with nine doubles, three home runs and 16 walks.
• Victor Scott II is hitting .284 with six doubles, a triple, two home runs and 12 walks.

Pirates vs Cardinals Head to Head

• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/19/2024: 3-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/18/2024: 10-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/17/2024: 3-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/16/2024: 4-0 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/24/2024: 5-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/23/2024: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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