Penguins vs Panthers NHL Prediction, Odds, Picks, Best Bets for Oct. 22

The Thursday schedule in the NHL includes a matchup between the Pittsburgh Penguins and the Florida Panthers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Penguins vs Panthers Game Info

• Pittsburgh Penguins (3-6-1) vs. Florida Panthers (5-3-2)
• Date: Thursday, October 22, 2026
• Time: 7 p.m. ET
• Venue: PPG Paints Arena -- Pittsburgh, Pennsylvania
• Coverage: ESPN+

Penguins vs Panthers Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Penguins vs Panthers Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Penguins win (64.9%)

Penguins vs Panthers Puck Line

• The Penguins are 1.5-goal favorites against the Panthers. The Penguins are +190 to cover the spread, and the Panthers are -240.

Penguins vs Panthers Over/Under

• An over/under of 6.5 has been set for Penguins-Panthers on Oct. 22, with the over being -140 and the under +114.

Penguins vs Panthers Moneyline

• Looking at the moneyline for Penguins-Panthers, Pittsburgh is the favorite at -115, and Florida is -105 playing on the road.

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