Patriots vs Seahawks Prediction: 10 Best Bets and Player Props for NFL Opening Night

NFL Betting Picks & Player Props in Summary

• Seahawks -3.5
• Under 44.5
• Jaxon Smith-Njigba Over 81.5 Receiving Yards
• A.J. Brown Over 62.5 Receiving Yards
• Rhamondre Stevenson Over 55.5 Rushing Yards
• Jadarian Price Anytime Touchdown
• Sam Darnold 2+ Passing Touchdowns
• Drake Maye Over 234.5 Passing Yards
• George Holani Anytime Touchdown
• Jadarian Price or Rhamondre Stevenson Anytime Touchdown

The Patriots and Seahawks kick off the NFL season Wednesday night in a genuine Super Bowl LX rematch, and the prop board reflects it — real, deep markets on both sides with a lot to work through before the opener.

All NFL odds come from FanDuel Sportsbook's NFL betting odds and may change after this article is published.

NFL Predictions and Picks

New England Patriots at Seattle Seahawks (Wed, 8:15 p.m. ET)

Seahawks -3.5 (-104)

A modest home favorite in a genuine Super Bowl rematch, with a real, deep receiving corps on both sides suggesting this comes down to execution rather than a clear talent gap.

Under 44.5 (-110)

The two team totals combine to 44 points on their own, essentially matching this number exactly — a genuinely fair reflection of how the market expects the scoring to break down in Week 1.

Best Player Props

Jaxon Smith-Njigba Over 81.5 Receiving Yards (-114)

Smith-Njigba is priced at an almost unthinkable -10000 just to record a single 10-yard catch, a genuine sign he's expected to see heavy volume all game — his full yardage line reflects that same confidence.

A.J. Brown Over 62.5 Receiving Yards (-114)

Brown is priced at -2500 just to clear a single 10-yard catch, the clear top target in New England's passing attack against a Seattle secondary he'll be tested against all night.

Rhamondre Stevenson Over 55.5 Rushing Yards (-114)

Stevenson is also the shortest price on the entire anytime touchdown board at +110, a genuine sign he's expected to carry a heavy workload for New England's offense in the opener.

Jadarian Price Anytime Touchdown (+135)

Price also has a real rushing line (51.5 yards) and is tied for the second-shortest anytime touchdown price on the board — a genuine lead-back workload for Seattle in the opener.

Sam Darnold 2+ Passing Touchdowns (+114)

With Smith-Njigba drawing that much confidence in the market, Darnold clearing two touchdown passes is a genuinely fair plus-money number for a favored offense at home.

Drake Maye Over 234.5 Passing Yards (-114)

Maye's own line sits slightly ahead of Darnold's, and with A.J. Brown drawing heavy volume in his own right, the yardage should be there even if New England trails on the scoreboard.

George Holani Anytime Touchdown (+185)

Holani rounds out Seattle's real backfield behind Price, and a plus-money price this deep into the touchdown market still reflects a genuine role in a Seahawks offense favored to score.

Jadarian Price or Rhamondre Stevenson Anytime Touchdown (-230)

Combining the two shortest touchdown prices on the entire board into one bet is a genuinely safe way to back the game's clearest workhorse backs without picking just one.