Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 5:13 a.m.

On Friday in MLB, the San Diego Padres are playing the Chicago White Sox.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs White Sox Game Info

• San Diego Padres (19-11) vs. Chicago White Sox (14-17)
• Date: Friday, May 1, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and CHSN

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | CHW: (+124)
• Spread: SD: -1.5 (+134) | CHW: +1.5 (-162)
• Total: 8 -- Over: (-115) | Under: (-105)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: German Marquez (Padres) - 3-1, 4.38 ERA vs Noah Schultz (White Sox) - 1-1, 3.52 ERA

This contest's pitching matchup is set, as the Padres will send German Marquez (3-1) to the mound, while Noah Schultz (1-1) will take the ball for the White Sox. Marquez's team is 4-1-0 against the spread this season in his starts. Marquez's team won his only start as a favorite this season. The White Sox have a 1-2-0 ATS record in Schultz's three starts that had a set spread. The White Sox were the moneyline underdog for two Schultz starts this season -- they split the games.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.1%)

Padres vs White Sox Moneyline

• Looking at the moneyline for White Sox-Padres, Chicago is the underdog at +124, and San Diego is -146 playing at home.

Padres vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Padres. The White Sox are -162 to cover the spread, and the Padres are +134.

Padres vs White Sox Over/Under

• The over/under for the Padres versus White Sox game on May 1 has been set at 8, with -115 odds on the over and -105 odds on the under.

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Padres vs White Sox Betting Trends

• The Padres have come away with 10 wins in the 15 contests they have been listed as the favorites in this season.
• This season San Diego has been victorious eight times in nine chances when named as a favorite of at least -146 on the moneyline.
• The Padres and their opponents have hit the over in 14 of their 30 games with a total set by oddsmakers this season.
• The Padres have posted a record of 19-11-0 against the spread this season.
• The White Sox have been the moneyline underdog 26 total times this season. They've gone 11-15 in those games.
• When playing as a moneyline underdog with odds of +124 or longer, Chicago has gone 5-10 (33.3%).
• The White Sox have played in 29 games with an over/under set, and have combined with opponents to go over the total 16 times (16-13-0).
• The White Sox have a 15-14-0 record against the spread this season.

Padres Player Leaders

• Xander Bogaerts leads San Diego with an OBP of .352, plus a team-best slugging percentage of .431. He's batting .275 on the season.
• Among all qualifying hitters, he is 49th in batting average, his on-base percentage ranks 60th, and he is 71st in slugging.
• Manny Machado is hitting .222 with four doubles, four home runs and 17 walks, while slugging .384 with an on-base percentage of .331.
• He ranks 133rd in batting average, 88th in on-base percentage and 104th in slugging among qualifying batters.
• Ramon Laureano has 27 hits and is batting .252 this season.
• Jackson Merrill is batting .200 with a .270 OBP and 15 RBI for San Diego this season.

White Sox Player Leaders

• Miguel Vargas is batting .215 with four doubles, a triple, six home runs and 24 walks. He's slugging .439 with an on-base percentage of .366.
• Including all the qualifying hitters in MLB, his batting average ranks 141st, his on-base percentage ranks 39th, and he is 65th in slugging.
• Vargas hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .250 with a double, a home run, seven walks and two RBIs.
• Munetaka Murakami has 26 hits with a .375 on-base percentage to pace his team in both. He has a batting average of .236 while slugging .564.
• His batting average is 109th among all qualified players, his on-base percentage is 29th, and he is 14th in slugging.
• Colson Montgomery has five doubles, eight home runs and 10 walks while batting .234.
• Chase Meidroth's .339 slugging percentage leads his team.

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