Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 5:12 a.m.

The San Diego Padres versus the Colorado Rockies is on the MLB schedule for Wednesday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Rockies Game Info

• San Diego Padres (16-7) vs. Colorado Rockies (9-15)
• Date: Wednesday, April 22, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Padres.TV

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-166) | COL: (+140)
• Spread: SD: -1.5 (-113) | COL: +1.5 (-106)
• Total: 12 -- Over: (-110) | Under: (-110)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 1-1, 4.58 ERA vs Tomoyuki Sugano (Rockies) - 1-1, 3.92 ERA

The Padres will look to Walker Buehler (1-1) against the Rockies and Tomoyuki Sugano (1-1). Buehler and his team have covered in each of his four starts with a spread this season. Buehler's team is 1-1 this season when he starts and they're favored on the moneyline. When Sugano starts, the Rockies are 2-2-0 against the spread. The Rockies are 2-2 in Sugano's four starts this season that they were the moneyline underdog.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.6%)

Padres vs Rockies Moneyline

• Looking at the moneyline for Rockies-Padres, Colorado is the underdog at +140, and San Diego is -166 playing on the road.

Padres vs Rockies Spread

• The Rockies are at +1.5 on the runline against the Padres. The Rockies are -106 to cover the spread, and the Padres are -113.

Padres vs Rockies Over/Under

• The Padres-Rockies contest on April 22 has been given an over/under of 12 runs. The over is set at -110 and the under at -110.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have been chosen as favorites in 10 games this year and have walked away with the win eight times (80%) in those games.
• San Diego has been a -166 moneyline favorite on four occasions this season and won every time.
• The Padres and their opponents have gone over in nine of their 23 games with a total set by sportsbooks this season.
• The Padres are 15-8-0 against the spread in their 23 games that had a posted line this season.
• The Rockies have won nine of the 24 games they were the moneyline underdog this season (37.5%).
• In games it has played as a moneyline underdog with odds of +140 or longer, Colorado has gone 6-14 (30%).
• The Rockies have played in 24 games with an over/under set, and have combined with opponents to go over the total nine times (9-15-0).
• The Rockies have put together a 15-9-0 record ATS this season.

Padres Player Leaders

• Xander Bogaerts has an OPS of .735, fueled by an OBP of .337 and a team-best slugging percentage of .398 this season. He has a .265 batting average.
• He ranks 61st in batting average, 79th in on-base percentage, and 86th in slugging among qualifying batters in baseball.
• Bogaerts hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .188 with three walks and an RBI.
• Ramon Laureano has 21 hits, which is best among San Diego batters this season. He's batting .259 with nine extra-base hits. He's also slugging .481 with an on-base percentage of .315.
• He is 70th in batting average, 114th in on-base percentage and 43rd in slugging among qualified hitters.
• Jackson Merrill has collected 19 base hits, an OBP of .271 and a slugging percentage of .382 this season.
• Fernando Tatis Jr. has a slash line of .265/.347/.313 this season and a team-best OPS of .660.
• Tatis brings a three-game hitting streak into this game. In his last five games he is batting .353 with three walks and four RBIs.

Rockies Player Leaders

• Mickey Moniak has three doubles, six home runs and three walks while batting .271. He's slugging .627 with an on-base percentage of .302.
• Moniak heads into this game on a six-game hitting streak. During his last 10 outings he is hitting .286 with three doubles, three home runs, two walks and seven RBIs.
• Troy Johnston paces his team with 21 hits and a .360 OBP, with a team-best .478 slugging percentage. He has a batting average of .304.
• He is 18th in batting average, 50th in on-base percentage and 44th in slugging percentage in the big leagues.
• T.J. Rumfield has a double, a triple, three home runs and seven walks while hitting .244.
• Hunter Goodman is hitting .241 with four doubles, five home runs and six walks.

Padres vs Rockies Head to Head

• 4/21/2026: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/12/2026: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/11/2026: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2026: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/9/2026: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/14/2025: 9-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 9/13/2025: 11-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/12/2025: 4-2 COL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)

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