Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 5:12 a.m.

Wednesday's slate in the MLB includes a matchup between the Los Angeles Dodgers and the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (16-7) vs. San Francisco Giants (10-13)
• Date: Wednesday, April 22, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-210) | SF: (+176)
• Spread: LAD: -1.5 (-120) | SF: +1.5 (+100)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Shohei Ohtani (Dodgers) - 2-0, 0.50 ERA vs Tyler Mahle (Giants) - 0-3, 7.23 ERA

The Dodgers will give the nod to Shohei Ohtani (2-0, 0.50 ERA), who is eyeing win No. 3 on the season, and the Giants will turn to Tyler Mahle (0-3, 7.23 ERA). Ohtani's team is 2-1-0 against the spread this season in his starts. When Ohtani starts a game and his team is the favorite on the moneyline, they have a record of 2-1. The Giants are 1-3-0 ATS in Mahle's four starts with a set spread. The Giants have a 1-2 record in Mahle's three starts this season when they were the underdog on the moneyline.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (60.2%)

Dodgers vs Giants Moneyline

• Looking at the moneyline for Giants-Dodgers, San Francisco is the underdog at +176, and Los Angeles is -210 playing on the road.

Dodgers vs Giants Spread

• The Giants are +1.5 on the run line against the Dodgers. The Giants are +100 to cover, and the Dodgers are -120.

Dodgers vs Giants Over/Under

• An over/under of 7.5 has been set for Dodgers-Giants on April 22, with the over being -122 and the under +100.

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Dodgers vs Giants Betting Trends

• The Dodgers have been chosen as favorites in 23 games this year and have walked away with the win 16 times (69.6%) in those games.
• This season Los Angeles has been victorious nine times in 11 chances when named as a favorite of at least -210 on the moneyline.
• Contests with the Dodgers have gone over the total set by bookmakers in 11 of 23 chances this season.
• The Dodgers have posted a record of 12-11-0 against the spread this season.
• The Giants have been the underdog on the moneyline 15 total times this season. They've gone 7-8 in those games.
• San Francisco has not yet played as a moneyline underdog of +176 or longer.
• The Giants have played in 23 games with a set over/under, and have combined with opponents to go over the total 10 times (10-10-3).
• The Giants have covered just 34.8% of their games this season, going 8-15-0 ATS.

Dodgers Player Leaders

• Andy Pages has an OPS of 1.009, fueled by an OBP of .411 to go with a slugging percentage of .598. He has a .366 batting average, as well.
• He ranks first in batting average, 10th in on-base percentage, and eighth in slugging among qualifying hitters in MLB.
• Freddie Freeman is hitting .289 with seven doubles, a triple, three home runs and nine walks, while slugging .506 with an on-base percentage of .366.
• Among all qualifying hitters, he is 30th in batting average, 44th in on-base percentage and 31st in slugging percentage.
• Ohtani has 23 hits this season and has a slash line of .271/.396/.494.
• Ohtani has picked up a hit in five straight games. In his last five games he is hitting .318 with three doubles, two walks and an RBI.
• Max Muncy has 23 hits, which ranks first among Los Angeles hitters this season, while batting .291 with nine extra-base hits.

Giants Player Leaders

• Luis Arraez has accumulated a team-best .360 slugging percentage. He's batting .302 with an on-base percentage of .333.
• Including all the qualified hitters in the majors, he is 19th in batting average, 88th in on-base percentage and 117th in slugging percentage.
• Matt Chapman is slugging .385 to pace his team. He has a batting average of .286 with an on-base percentage of .337.
• His batting average is 34th among all qualified players, his on-base percentage is 79th, and he is 95th in slugging.
• Jung Hoo Lee is batting .259 with six doubles, a home run and seven walks.
• Willy Adames is batting .247 with 10 doubles, three home runs and five walks.

Dodgers vs Giants Head to Head

• 4/21/2026: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -186, Underdog Moneyline: +144)
• 9/21/2025: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/20/2025: 7-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/18/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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