Diamondbacks vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 5:11 a.m.

The Wednesday slate in MLB includes a matchup between the Arizona Diamondbacks and the Chicago White Sox.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs White Sox Game Info

• Arizona Diamondbacks (13-10) vs. Chicago White Sox (9-14)
• Date: Wednesday, April 22, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and CHSN

Diamondbacks vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-152) | CHW: (+128)
• Spread: ARI: -1.5 (+130) | CHW: +1.5 (-156)
• Total: 9 -- Over: (-122) | Under: (+100)

Diamondbacks vs White Sox Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 1-0, 1.96 ERA vs Anthony Kay (White Sox) - 1-0, 2.60 ERA

The Diamondbacks will give the ball to Eduardo Rodriguez (1-0, 1.96 ERA), who is eyeing win No. 2 on the season, and the White Sox will counter with Anthony Kay (1-0, 2.60 ERA). Rodríguez's team is 3-1-0 against the spread this season in his starts. This will be Rodriguez's first game as the moneyline favorite this season. Kay has started two games with set spreads, and the White Sox went 1-1-0. The White Sox were the moneyline underdog for two Kay starts this season -- they split the games.

Diamondbacks vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (64.9%)

Diamondbacks vs White Sox Moneyline

• Chicago is a +128 underdog on the moneyline, while Arizona is a -152 favorite at home.

Diamondbacks vs White Sox Spread

• The Diamondbacks are 1.5-run home favorites on the runline against the White Sox. The Diamondbacks are +130 to cover, and the White Sox are -156.

Diamondbacks vs White Sox Over/Under

• A total of 9 runs has been set for the Diamondbacks-White Sox contest on April 22, with the over available at -122 and the under at +100.

Bet on Arizona Diamondbacks vs. Chicago White Sox on FanDuel today!

Diamondbacks vs White Sox Betting Trends

• The Diamondbacks have been favorites in six games this season and have come away with the win five times (83.3%) in those contests.
• Arizona has played as a favorite of -152 or more just one time this year and came away with a win in that game.
• Contests with the Diamondbacks have gone over the total set by sportsbooks in 14 of 23 chances this season.
• The Diamondbacks have an against the spread record of 17-6-0 in 23 games with a line this season.
• The White Sox have been the moneyline underdog 22 total times this season. They've finished 8-14 in those games.
• When it has played as a moneyline underdog with odds of +128 or longer, Chicago has a 5-7 record (winning 41.7% of its games).
• The White Sox have had an over/under set by oddsmakers 22 times, and have combined with opponents to go over the total in 14 of those games (14-8-0).
• The White Sox have covered 45.5% of their games this season, going 10-12-0 against the spread.

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona with 21 hits and an OBP of .391 this season. He has a .288 batting average and a slugging percentage of .575.
• He ranks 32nd in batting average, 19th in on-base percentage, and 11th in slugging among qualified hitters in the majors.
• Ildemaro Vargas leads Arizona in slugging percentage (.623) thanks to nine extra-base hits. He's batting .361 with an on-base percentage of .381.
• Vargas has picked up at least one hit in 16 straight games. In his last 10 outings he is batting .293 with four doubles, two home runs, a walk and seven RBIs.
• Geraldo Perdomo has collected 17 base hits, an OBP of .341 and a slugging percentage of .342 this season.
• Perdomo takes a five-game hitting streak into this matchup. During his last five outings he is batting .474 with a double, a triple, two walks and an RBI.
• Ketel Marte has four home runs, nine RBI and a batting average of .218 this season.
• Marte has safely hit in two straight games. In his last five games he is hitting .238 with two walks.

White Sox Player Leaders

• Munetaka Murakami has an on-base percentage of .394 and has 18 hits, both team-high numbers for the White Sox. He's batting .234 and slugging .584.
• Including all qualified hitters in the big leagues, he is 107th in batting average, 17th in on-base percentage and 10th in slugging percentage.
• Murakami brings a four-game hitting streak into this game. During his last five outings he is batting .381 with four home runs, four walks and eight RBIs.
• Miguel Vargas is hitting .177 with three doubles, a triple, four home runs and 15 walks. He's slugging .392 with an on-base percentage of .320.
• He is currently 167th in batting average, 110th in on-base percentage and 91st in slugging percentage among all qualified hitters.
• Colson Montgomery is hitting .213 with five doubles, six home runs and nine walks.
• Chase Meidroth is slugging .354 to lead his team.

Diamondbacks vs White Sox Head to Head

• 4/21/2026: 11-5 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 6/25/2025: 7-3 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/24/2025: 4-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/23/2025: 10-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/16/2024: 12-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/15/2024: 9-2 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2024: 7-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/28/2023: 3-1 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/27/2023: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/26/2023: 15-4 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)

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