Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 10:16 a.m.

The San Diego Padres are among the MLB squads playing on Wednesday, up against the Cincinnati Reds.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (79-66) vs. Cincinnati Reds (73-72)
• Date: Wednesday, September 10, 2025
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-148) | CIN: (+126)
• Spread: SD: -1.5 (+146) | CIN: +1.5 (-178)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 13-5, 2.85 ERA vs Andrew Abbott (Reds) - 8-6, 2.88 ERA

This contest's pitching matchup is set, as the Padres will send Nick Pivetta (13-5) to the mound, while Andrew Abbott (8-6) will get the nod for the Reds. Pivetta's team is 16-12-0 against the spread this season in his starts. When Pivetta starts a game and his team is the favorite on the moneyline, they have a record of 11-7. The Reds are 13-11-0 against the spread when Abbott starts. The Reds have been the underdog on the moneyline in nine of Abbott's starts this season, and they went 5-4 in those matchups.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.9%)

Padres vs Reds Moneyline

• Looking at the moneyline for Reds-Padres, Cincinnati is the underdog at +126, and San Diego is -148 playing at home.

Padres vs Reds Spread

• The Padres are hosting the Reds and are favored by 1.5 runs on the spread. The Padres are +146 to cover the runline, with the Reds being -178.

Padres vs Reds Over/Under

• The Padres-Reds contest on Sept. 10 has been given an over/under of 7.5 runs. The over is set at -112 and the under at -108.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have been victorious in 46, or 59.7%, of the 77 contests they have been chosen as favorites in this season.
• San Diego has a record of 25-17 in contests when bookmakers favor them by -148 or more on the moneyline.
• The Padres and their opponents have hit the over in 62 of their 143 games with a total set by oddsmakers this season.
• The Padres have posted a record of 77-66-0 against the spread this season.
• The Reds have compiled a 37-41 record in games they were the underdog on the moneyline (winning 47.4% of those games).
• In games it has played as a moneyline underdog with odds of +126 or longer, Cincinnati has a record of 15-15 (50%).
• In the 138 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 54 times (54-76-8).
• The Reds have a 72-66-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 20 home runs and 84 walks while batting .261. He has an on-base percentage of .365 and a slugging percentage of .429.
• Among qualifying batters in baseball, he ranks 70th in batting average, 15th in on-base percentage, and 78th in slugging.
• Manny Machado is hitting .276 with 33 doubles, 23 home runs and 51 walks. He's slugging .458 with an on-base percentage of .337.
• He is 29th in batting average, 54th in on-base percentage and 50th in slugging among qualifying batters.
• Luis Arraez has an OPS of .703, fueled by an OBP of .318 and a team-best slugging percentage of .386 this season.
• Ramon Laureano has 23 home runs, 71 RBI and a batting average of .295 this season.

Reds Player Leaders

• Elly De La Cruz has put up a slugging percentage of .442 and has 152 hits, both team-best numbers for the Reds. He's batting .267 and with an on-base percentage of .335.
• Including all qualified players in MLB, his batting average places him 48th, his on-base percentage is 60th, and he is 68th in slugging.
• De La Cruz heads into this game on a three-game hitting streak. During his last five outings he is hitting .200 with a double, a walk and three RBIs.
• TJ Friedl has a .363 OBP to pace his team. He has a batting average of .264 while slugging .380.
• He is currently 57th in batting average, 19th in on-base percentage and 126th in slugging percentage among all qualifying hitters.
• Spencer Steer is batting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays is hitting .265 with 15 doubles, five triples, 15 home runs and 27 walks.

Padres vs Reds Head to Head

• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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